Extracorporeal photopheresis for chronic graft-versus-host disease: a systematic review and meta-analysis
| العنوان: | Extracorporeal photopheresis for chronic graft-versus-host disease: a systematic review and meta-analysis |
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| المؤلفون: | Shahrukh K. Hashmi, William J. Hogan, Mrinal M. Patnaik, Jeffrey L. Winters, Larry J. Prokop, Mohsin Ilyas Malik, Mark R. Litzow, Mohammad Hassan Murad |
| المصدر: | Blood research |
| بيانات النشر: | The Korean Society of Hematology, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | medicine.medical_specialty, business.industry, Extracorporeal photopheresis, Hematology, Disease, medicine.disease, Graft-versus-host disease, Meta-analysis, Internal medicine, Extracorporeal Photopheresis, medicine, Original Article, business |
| الوصف: | Background The safety of extracorporeal photopheresis (ECP) in steroid-refractory chronic graft-versus-host disease (SR-cGVHD) has been explored in multiple studies but reported response rates (RR) vary significantly across studies. Methods We conducted a meta-analysis to assess the efficacy of ECP for SR-cGVHD. A search of electronic databases for studies published between 1984 and 2012 was conducted. End points included RR: complete response (CR), overall response rates (ORR), and organ-specific RR. The initial search generated 312 studies, of which 18 met the selection criteria (N=595). A random effects model was used for pooled rates. Results Pooled CR rates and ORR were 29% (confidence interval [CI], 19-42%) and 64% (CI, 65-82%), respectively. One-year overall survival was available for 4 studies only and was 49% (CI, 29-70%). The pooled RR for skin, liver, ocular, oral, lung, gastrointestinal and musculoskeletal SR-cGVHD was 74%, 68%, 60%, 72%, 48%, 53%, and 64%, respectively. There was a significant heterogeneity among studies due to differences in ECP schedules and duration. No significant differences in responses to ECP for pediatric and adult populations were found. Sensitivity analysis could not be undertaken due to a limited number of prospective studies. Conclusion ECP is an effective therapy for oral, skin, and liver SR-cGVHD, with modest activity in lung and gastrointestinal SR-cGVHD. |
| تدمد: | 2288-0011 2287-979X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ba3d1db50603148c8733be8ba1e4bd9Test https://doi.org/10.5045/br.2014.49.2.100Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....3ba3d1db50603148c8733be8ba1e4bd9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22880011 2287979X |
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