Toxicokinetics of paraquat in Korean patients with acute poisoning
| العنوان: | Toxicokinetics of paraquat in Korean patients with acute poisoning |
|---|---|
| المؤلفون: | Jun Seok Bae, Hyung Ki Kim, Hyo-Wook Gil, Sae-Yong Hong, Hwa Young Lee, Hak-Jae Kim, Jun Tack Kown |
| المصدر: | The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology |
| بيانات النشر: | The Korean Physiological Society and The Korean Society of Pharmacology, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Paraquat, Pharmacology, Volume of distribution, Physiology, business.industry, Poisoning, 030232 urology & nephrology, Cmax, Poison control, Urine, Acute toxicity, Toxicokinetics, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, chemistry, Anesthesia, Medicine, Ingestion, Original Article, 030212 general & internal medicine, business |
| الوصف: | To conduct a kinetic study of paraquat (PQ), we investigated 9 patients with acute PQ intoxication. All of them ingested more than 20 ml of undiluted PQ herbicide to commit suicide and arrived at our hospital early, not later than 7 h after PQ ingestion. The urine dithionite test for PQ in all of the nine patients was strongly positive at emergency room. Blood samples were obtained every 30 min for the first 2~3 h and then every 1 or 2 h, as long as the clinical progression was stable among the patients for 30 h after PQ ingestion. The area under the plasma concentration-time curve (AUCinf), which was extrapolated to infinity, was calculated using the trapezoidal rule. Toxicokinetic parameters, such as the terminal elimination half-life, apparent oral clearance, and apparent volume of distribution (Vd/F) were calculated. The maximum PQ concentration (Cmax) and the time to reach maximum PQ concentration (Tmax) were also obtained. Plasma PQ concentrations in nine patients were well described by a bi-exponential curve with a mean terminal elimination half-life of 13.1±6.8 h. Cmax and AUCinf were 20.8±25.7 mg/l and 172.5±160.3 h·mg/l, respectively. Apparent volume of distribution and apparent oral clearance were 50.9±61.3 l/kg and 173.4±111.2 l/h, respectively. There were a significant correlation (r =0.84; p |
| تدمد: | 2093-3827 1226-4512 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d1a2777517b1ef21e3beb4a5f1aba5dTest https://doi.org/10.4196/kjpp.2016.20.1.35Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....8d1a2777517b1ef21e3beb4a5f1aba5d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20933827 12264512 |
|---|