دورية أكاديمية
أعرض في EDS

The adjuvant GLA-SE promotes human Tfh cell expansion and emergence of public TCRβ clonotypes

التفاصيل البيبلوغرافية
العنوان: The adjuvant GLA-SE promotes human Tfh cell expansion and emergence of public TCRβ clonotypes
المؤلفون: Hill, Danika L, Pierson, Wim, Bolland, Daniel J, Mkindi, Catherine, Carr, Edward J, Wang, Jiong, Houard, Sophie, Wingett, Steven W, Audran, Regine, Wallin, Elizabeth F, Jongo, Said A, Kamaka, Kassim, Zand, Martin, Spertini, Francois, Daubenberger, Claudia, Corcoran, Anne E, Linterman, Michelle A
بيانات النشر: Rockefeller University Press
//elements.admin.cam.ac.uk/objectedit.html?cid=1&ot=5&oid=1101279&rid=3074962
The Journal of Experimental Medicine
سنة النشر: 2019
المجموعة: Apollo - University of Cambridge Repository
مصطلحات موضوعية: Adjuvants, Immunologic, Adolescent, Adult, Aged, 80 and over, Aluminum Hydroxide, Antibodies, Viral, Antigens, Protozoan, B-Lymphocytes, Cells, Cultured, Drug Compounding, Female, Germinal Center, Glucosides, Humans, Immunity, Humoral, Influenza Vaccines, Lipid A, Lymph Nodes, Malaria Vaccines, Male, Middle Aged, Plasmodium falciparum, Receptors, Antigen
الوصف: The generation of protective humoral immunity after vaccination relies on the productive interaction between antigen-specific B cells and T follicular helper (Tfh) cells. Despite the central role of Tfh cells in vaccine responses, there is currently no validated way to enhance their differentiation in humans. From paired human lymph node and blood samples, we identify a population of circulating Tfh cells that are transcriptionally and clonally similar to germinal center Tfh cells. In a clinical trial of vaccine formulations, circulating Tfh cells were expanded in Tanzanian volunteers when an experimental malaria vaccine was adjuvanted in GLA-SE but not when formulated in Alum. The GLA-SE–formulated peptide was associated with an increase in the extrafollicular antibody response, long-lived antibody production, and the emergence of public TCRβ clonotypes in circulating Tfh cells. We demonstrate that altering vaccine adjuvants is a rational approach for enhancing Tfh cells in humans, thereby supporting the long-lived humoral immunity that is required for effective vaccines.
نوع الوثيقة: article in journal/newspaper
وصف الملف: application/pdf
اللغة: English
العلاقة: https://www.repository.cam.ac.uk/handle/1810/293842Test
DOI: 10.17863/CAM.40954
الإتاحة: https://doi.org/10.17863/CAM.40954Test
https://www.repository.cam.ac.uk/handle/1810/293842Test
حقوق: Attribution 4.0 International ; http://creativecommons.org/licenses/by/4.0Test/
رقم الانضمام: edsbas.8BB152C3
قاعدة البيانات: BASE
الوصف
DOI:10.17863/CAM.40954