دورية أكاديمية
IgG4-related skin lesions in a patient with IgG4-related chronic sclerosing dacryoadenitis and sialoadenitis
| العنوان: | IgG4-related skin lesions in a patient with IgG4-related chronic sclerosing dacryoadenitis and sialoadenitis |
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| المؤلفون: | Kakuchi Yasushi, Yamada Kazunori, Suzuki Yasunori, Ito Naoko, Yagi Kunimasa, Matsumura Masami, Yamagishi Masakazu, Umehara Hisanori, Zen Yoh, Hasegawa Minoru, Takehara Kazuhiko, Kawano Mitsuhiro |
| بيانات النشر: | The Japanese Society of Internal Medicine |
| سنة النشر: | 2011 |
| المجموعة: | Kanazawa University Repository for Academic Resources (KURA) / 金沢大学学術情報リポジトリ |
| مصطلحات موضوعية: | Cutaneous lymphoid infiltrate, IgG4-related chronic sclerosing dacryoadenitis and sialoadenitis, IgG4-related disease |
| الوصف: | We describe a 60-year-old man with IgG4-related chronic sclerosing dacryoadenitis and sialoadenitis associated with lymphoplasmacytic and eosinophilic infiltration in erythematous nodules. Physical examination revealed left eye extrusion and small itchy nodules on the scalp and neck. The serum IgG level was 1,570 mg/dL, IgG4 463 mg/dL (29.5%), and IgE 4,554 IU/mL. Lacrimal gland biopsy disclosed prominent infiltrates of IgG4-positive plasma cells and scattered eosinophilic infiltrates with fibrosis, consistent with IgG4-related disease. A skin biopsy of a cutaneous nodule demonstrated that the infiltrated plasma cells around arterioles or venules in the deep dermis and subcutaneous fat tissue were strongly positive for IgG4. Although the swollen lacrimal and parotid gland and itchy subcutaneous erythematous nodules improved rapidly with oral prednisolone at a dose of 20 mg per day, the skin, lacrimal, and parotid lesions deteriorated simultaneously during steroid tapering and improved after increasing the dosage. As skin lesions are easy to biopsy, further study of the skin manifestations of IgG4-related disease will be important in further clarifying the clinical spectrum, pathophysiology and response to therapy of this disorder. © 2011 The Japanese Society of Internal Medicine. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0918-2918 |
| العلاقة: | https://japanlinkcenter.org/JST.JSTAGE/internalmedicine/50.5239Test; http://www.naika.or.jp/imonline/index.htmlTest; https://kanazawa-u.repo.nii.ac.jp/?action=repository_uri&item_id=26741Test; http://hdl.handle.net/2297/29196Test; Internal Medicine, 50(14), 1465-1469(2011-01-01); AA10827774; https://kanazawa-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=26741&item_no=1&attribute_id=26&file_no=1Test |
| الإتاحة: | http://hdl.handle.net/2297/29196Test https://kanazawa-u.repo.nii.ac.jp/?action=repository_uri&item_id=26741Test https://kanazawa-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=26741&item_no=1&attribute_id=26&file_no=1Test |
| حقوق: | Copyright (c) 2011 by The Japanese Society of Internal Medicine |
| رقم الانضمام: | edsbas.3842292 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 09182918 |
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