دورية أكاديمية
The β Cell in Diabetes: Integrating Biomarkers With Functional Measures.
| العنوان: | The β Cell in Diabetes: Integrating Biomarkers With Functional Measures. |
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| المؤلفون: | Kahn, Steven E., Chen, Yi-Chun, Esser, Nathalie, Taylor, Austin J., van Raalte, Daniël H., Zraika, Sakeneh, Verchere, C. Bruce |
| المصدر: | Endocrine Reviews, 42 (5), 528-583 (2021) |
| بيانات النشر: | The Endocrine Society |
| سنة النشر: | 2021 |
| المجموعة: | University of Liège: ORBi (Open Repository and Bibliography) |
| مصطلحات موضوعية: | genetics, imaging, immunology, insulin, islet amyloid polypeptide, Human health sciences, Endocrinology, metabolism & nutrition, Sciences de la santé humaine, Endocrinologie, métabolisme & nutrition |
| الوصف: | peer reviewed ; The pathogenesis of hyperglycemia observed in most forms of diabetes is intimately tied to the islet β cell. Impairments in propeptide processing and secretory function, along with the loss of these vital cells, is demonstrable not only in those in whom the diagnosis is established but typically also in individuals who are at increased risk of developing the disease. Biomarkers are used to inform on the state of a biological process, pathological condition, or response to an intervention and are increasingly being used for predicting, diagnosing, and prognosticating disease. They are also proving to be of use in the different forms of diabetes in both research and clinical settings. This review focuses on the β cell, addressing the potential utility of genetic markers, circulating molecules, immune cell phenotyping, and imaging approaches as biomarkers of cellular function and loss of this critical cell. Further, we consider how these biomarkers complement the more long-established, dynamic, and often complex measurements of β-cell secretory function that themselves could be considered biomarkers. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0163-769X |
| العلاقة: | urn:issn:0163-769X; https://orbi.uliege.be/handle/2268/267274Test; info:hdl:2268/267274; scopus-id:2-s2.0-85117333679; info:pmid:34180979 |
| DOI: | 10.1210/endrev/bnab021 |
| الإتاحة: | https://doi.org/10.1210/endrev/bnab021Test https://orbi.uliege.be/handle/2268/267274Test |
| حقوق: | restricted access ; http://purl.org/coar/access_right/c_16ecTest ; info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: | edsbas.B47A3C25 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 0163769X |
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| DOI: | 10.1210/endrev/bnab021 |