Effects of Taurocholic Acid on Glycemic, Glucagon-like Peptide-1, and Insulin Responses to Small Intestinal Glucose Infusion in Healthy Humans
| العنوان: | Effects of Taurocholic Acid on Glycemic, Glucagon-like Peptide-1, and Insulin Responses to Small Intestinal Glucose Infusion in Healthy Humans |
|---|---|
| المؤلفون: | Scott Standfield, Christopher K. Rayner, Michelle J. Bound, Karen L. Jones, Michael Horowitz, Tongzhi Wu |
| المساهمون: | Wu, Tongzhi, Bound, Michelle J, Standfield, Scott D, Jones, Karen L, Horowitz, Michael, Rayner, Christopher K |
| المصدر: | The Journal of Clinical Endocrinology & Metabolism. 98:E718-E722 |
| بيانات النشر: | The Endocrine Society, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Adult, Blood Glucose, Male, Taurocholic Acid, Cholagogues and Choleretics, endocrine system, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Clinical Biochemistry, receptors, Context (language use), Biochemistry, Glucagon, cytoplasmic and nuclear, chemistry.chemical_compound, Endocrinology, Double-Blind Method, Glucagon-Like Peptide 1, Internal medicine, Intestine, Small, Humans, Insulin, Medicine, bile acids and salts, Saline, Infusion Pumps, Glycemic, heterodimer partner, C-Peptide, business.industry, C-peptide, digestive, oral, and skin physiology, Biochemistry (medical), Taurocholic acid, Glucagon-like peptide-1, Glucose, chemistry, Health, business |
| الوصف: | Context: In vitro and animal studies suggest that bile acids have the capacity to reduce blood glucose by stimulating glucagon-like peptide-1 (GLP-1) and, thereby, insulin. Objective: This study evaluated the effects of intrajejunal taurocholic acid (TCA) on blood glucose, GLP-1, and insulin responses to jejunal glucose infusion in healthy men. Participants and Design: Ten healthy men were each studied on 2 days in a double-blind, randomized order. After the subjects fasted overnight, a jejunal catheter was positioned and a balloon inflated 30 cm beyond the pylorus with aspiration of endogenous bile. Two grams TCA in saline, or saline control, was infused beyond the balloon over 30 minutes, followed by 2 g TCA or control, together with 60 g glucose, over the next 120 minutes. Blood was sampled frequently for the measurements of blood glucose, total GLP-1, insulin, C-peptide, and glucagon. Results: Intrajejunal infusion of TCA alone (t = -30 to 0 minutes) had no effect on blood glucose, GLP-1, insulin, C-peptide, or glucagon concentrations. During intrajejunal glucose infusion (t = 0 to 120 minutes), blood glucose concentrations were lower (P< .001), and plasma GLP-1 (P < .001) and the C-peptide/glucose ratio (P = .008) were both greater, whereas plasma insulin, C-peptide, and glucagon levels were not significantly different after TCA than after control. Conclusions: In healthy humans, small intestinal infusion of TCA potently reduces the glycemic response to small intestinal glucose, associated with an increase in GLP-1 and C-peptide/glucose ratio. These observations indicate the potential for bile acid-based therapy in type 2 diabetes. Refereed/Peer-reviewed |
| تدمد: | 1945-7197 0021-972X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7ff51eed59d4a71867c8801be2184aeTest https://doi.org/10.1210/jc.2012-3961Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c7ff51eed59d4a71867c8801be2184ae |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19457197 0021972X |
|---|