Genetically Determined Reproductive Aging and Coronary Heart Disease: A Bidirectional 2-sample Mendelian Randomization
| العنوان: | Genetically Determined Reproductive Aging and Coronary Heart Disease: A Bidirectional 2-sample Mendelian Randomization |
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| المؤلفون: | Veerle Dam, N Charlotte Onland-Moret, Stephen Burgess, Maria-Dolores Chirlaque, Sanne A E Peters, Ewoud Schuit, Kaja Tikk, Elisabete Weiderpass, Clare Oliver-Williams, Angela M Wood, Anne Tjønneland, Christina C Dahm, Kim Overvad, Marie-Christine Boutron-Ruault, Matthias B Schulze, Antonia Trichopoulou, Pietro Ferrari, Giovanna Masala, Vittorio Krogh, Rosario Tumino, Giuseppe Matullo, Salvatore Panico, Jolanda M A Boer, W M Monique Verschuren, Marit Waaseth, Maria José Sánchez Pérez, Pilar Amiano, Liher Imaz, Conchi Moreno-Iribas, Olle Melander, Sophia Harlid, Maria Nordendahl, Patrik Wennberg, Timothy J Key, Elio Riboli, Carmen Santiuste, Rudolf Kaaks, Verena Katzke, Claudia Langenberg, Nicholas J Wareham, Heribert Schunkert, Jeanette Erdmann, Christina Willenborg, Christian Hengstenberg, Marcus E Kleber, Graciela Delgado, Winfried März, Stavroula Kanoni, George Dedoussis, Panos Deloukas, Majid Nikpay, Ruth McPherson, Markus Scholz, Andrej Teren, Adam S Butterworth, Yvonne T van der Schouw |
| المساهمون: | Dam, Veerle [0000-0002-5982-232X], Onland-Moret, N Charlotte [0000-0002-2360-913X], Burgess, Stephen [0000-0001-5365-8760], Chirlaque, Maria-Dolores [0000-0001-9242-3040], Schuit, Ewoud [0000-0002-9548-3214], Weiderpass, Elisabete [0000-0003-2237-0128], Overvad, Kim [0000-0001-6429-7921], Boutron-Ruault, Marie-Christine [0000-0002-5956-5693], Trichopoulou, Antonia [0000-0002-7204-6396], Ferrari, Pietro [0000-0001-9358-7338], Masala, Giovanna [0000-0002-5758-9069], Krogh, Vittorio [0000-0003-0122-8624], Panico, Salvatore [0000-0002-5498-8312], Harlid, Sophia [0000-0001-8540-6891], Riboli, Elio [0000-0001-6795-6080], Katzke, Verena [0000-0002-6509-6555], Schunkert, Heribert [0000-0001-6428-3001], Hengstenberg, Christian [0000-0002-8284-2994], Kleber, Marcus E [0000-0003-0663-7275], Deloukas, Panos [0000-0001-9251-070X], Nikpay, Majid [0000-0003-0285-6454], McPherson, Ruth [0000-0002-9087-6107], Scholz, Markus [0000-0002-4059-1779], Apollo - University of Cambridge Repository |
| المصدر: | Digibug. Repositorio Institucional de la Universidad de Granada instname Dam, V, Onland-Moret, N C, Burgess, S, Chirlaque, M-D, Peters, S A E, Schuit, E, Tikk, K, Weiderpass, E, Oliver-Williams, C, Wood, A M, Tjønneland, A, Dahm, C C, Overvad, K, Boutron-Ruault, M-C, Schulze, M B, Trichopoulou, A, Ferrari, P, Masala, G, Krogh, V, Tumino, R, Matullo, G, Panico, S, Boer, J M A, Verschuren, W M M, Waaseth, M, Sánchez Pérez, M J, Amiano, P, Imaz, L, Moreno-Iribas, C, Melander, O, Harlid, S, Nordendahl, M, Wennberg, P, Key, T J, Riboli, E, Santiuste, C, Kaaks, R, Katzke, V, Langenberg, C, Wareham, N J, Schunkert, H, Erdmann, J, Willenborg, C, Hengstenberg, C, Kleber, M E, Delgado, G, März, W, Kanoni, S, Dedoussis, G, Deloukas, P, Nikpay, M, McPherson, R, Scholz, M, Teren, A, Butterworth, A S & van der Schouw, Y T 2022, ' Genetically determined reproductive aging and coronary heart disease : A Bidirectional 2-sample Mendelian Randomization ', The Journal of clinical endocrinology and metabolism, vol. 107, no. 7, pp. e2952–e2961 . https://doi.org/10.1210/clinem/dgac171Test Dam, V, Onland-Moret, N C, Burgess, S, Chirlaque, M-D, Peters, S A E, Schuit, E, Tikk, K, Weiderpass, E, Oliver-Williams, C, Wood, A M, Tjønneland, A, Dahm, C C, Overvad, K, Boutron-Ruault, M-C, Schulze, M B, Trichopoulou, A, Ferrari, P, Masala, G, Krogh, V, Tumino, R, Matullo, G, Panico, S, Boer, J M A, Verschuren, W M M, Waaseth, M, Sánchez Pérez, M J, Amiano, P, Imaz, L, Moreno-Iribas, C, Melander, O, Harlid, S, Nordendahl, M, Wennberg, P, Key, T J, Riboli, E, Santiuste, C, Kaaks, R, Katzke, V, Langenberg, C, Wareham, N J, Schunkert, H, Erdmann, J, Willenborg, C, Hengstenberg, C, Kleber, M E, Delgado, G, März, W, Kanoni, S, Dedoussis, G, Deloukas, P, Nikpay, M, McPherson, R, Scholz, M, Teren, A, Butterworth, A S & van der Schouw, Y T 2022, ' Genetically determined reproductive aging and coronary heart disease : A Bidirectional 2-sample Mendelian Randomization ', The Journal of clinical endocrinology and metabolism, vol. 107, no. 7, pp. e2952-e2961 . https://doi.org/10.1210/clinem/dgac171Test |
| بيانات النشر: | The Endocrine Society, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Male, MENOPAUSE, Aging, IMPACT, Endocrinology, Diabetes and Metabolism, Clinical Biochemistry, Coronary Disease, VARIANTS, Biochemistry, Polymorphism, Single Nucleotide, AGE, Endocrinology, Mendelian Randomization, Aging/genetics, Reproductive aging, risk factors, Humans, cardiovascular diseases, GENOME-WIDE ASSOCIATION, coronary heart disease, Coronary Disease/epidemiology, RISK, MORTALITY, Biochemistry (medical), Mendelian Randomization Analysis, Coronary heart disease, BIAS, Risk factors, reproductive aging, Genome-Wide Association Study/methods, Female, FASTING GLUCOSE, Genome-Wide Association Study |
| الوصف: | The EPIC-CVD project was supported by the European Union Framework 7 (HEALTH-F2-2012-279233), the European Research Council (268834), the UK Medical Research Council (G0800270, MR/L003120/1), the British Heart Foundation (SP/09/002, RG/08/014, RG13/13/30194), and the UK National Institute of Health Research (to EPIC-CVD). The establishment of the subcohort was supported by the EU Sixth Framework Programme (FP6) (grant LSHM_CT_2006_037197 to the InterAct project) and the Medical Research Council Epidemiology Unit (grants MC_ UU_12015/1 and MC_UU_12015/5). The national EPIC cohorts are supported by Danish Cancer Society (Denmark); Ligue Contre le Cancer, Institut Gustave Roussy, Mutuelle Generale de l'Education Nationale, Institut National de la Sante et de la Recherche Medicale (INSERM) (France); Deutsche Krebshilfe, Deutsches Krebsforschungszentrum and Federal Ministry of Education and Research (Germany); Ministry of Health and Social Solidarity, Stavros Niarchos Foundation and Hellenic Health Foundation (Greece); Italian Association for Research on Cancer (AIRC) and National Research Council (Italy) and MIUR "Dipartimenti di Eccellenza"(Project D15D18000410001) to the Department of Medical Sciences; Dutch Ministry of Public Health, Welfare and Sports (VWS), LK Research Funds, Dutch Prevention Funds, Dutch ZON (Zorg Onderzoek Nederland), World Cancer Research Fund (WCRF); ERC-2009-AdG 232997 and Nordforsk, Nordic Centre of Excellence programme on Food, Nutrition and Health (Norway); Health Research Fund (FIS), Regional Governments of Andalucia, Asturias, Basque Country, Murcia and Navarra, ISCIII RETIC (RD06/0020) (Spain); Swedish Cancer Society, Swedish Scientific Council and Regional Government of Skane and Vasterbotten (Sweden); and Cancer Research UK, Medical Research Council (United Kingdom). LIFE-Heart is funded by the Leipzig Research Center for Civilization Diseases (LIFE). LIFE is an organizational unit affiliated to the Medical Faculty of the University of Leipzig. LIFE is funded by means of the European Union, by the European Regional Development Fund (ERDF), and by funds of the Free State of Saxony within the framework of the excellence initiative. This work is supported by the Dutch Heart Foundation (2013T083 to V.D.), by a UK Medical Research Council Skills Development Fellowship (MR/P014550/1 to S.A.E.P.), and by a Sir Henry Dale Fellowship jointly funded by the Welcome Trust and the Royal Society (204623/Z/16/Z to S.B.). None of the funding sources had a role in the collection, analysis, and interpretation of the data, nor in the decision to submit the article for publication. Background: Accelerated reproductive aging, in women indicated by early natural menopause, is associated with increased coronary heart disease (CHD) risk in observational studies. Conversely, an adverse CHD risk profile has been suggested to accelerate menopause. Objectives: To study the direction and evidence for causality of the relationship between reproductive aging and (non-)fatal CHD and CHD risk factors in a bidirectional Mendelian randomization (MR) approach, using age at natural menopause (ANM) genetic variants as a measure for genetically determined reproductive aging in women. We also studied the association of these variants with CHD risk (factors) in men. Design: Two-sample MR, using both cohort data as well as summary statistics, with 4 methods: simple and weighted median-based, standard inverse-variance weighted (IVW) regression, and MR-Egger regression. Participants: Data from EPIC-CVD and summary statistics from UK Biobank and publicly available genome-wide association studies were pooled for the different analyses. Main Outcome Measures: CHD, CHD risk factors, and ANM. Results: Across different methods of MR, no association was found between genetically determined reproductive aging and CHD risk in women (relative risk estimateIVW = 0.99; 95% confidence interval (CI), 0.97-1.01), or any of the CHD risk factors. Similarly, no associations were found in men. Neither did the reversed analyses show evidence for an association between CHD (risk factors) and reproductive aging. Conclusion: Genetically determined reproductive aging is not causally associated with CHD risk (factors) in women, nor were the genetic variants associated in men. We found no evidence for a reverse association in a combined sample of women and men. European Commission HEALTH-F2-2012-279233 European Research Council (ERC) European Commission 268834 UK Research & Innovation (UKRI) Medical Research Council UK (MRC) G0800270 MR/L003120/1 British Heart Foundation SP/09/002 RG/08/014 RG13/13/30194 National Institute for Health Research (NIHR) EU Sixth Framework Programme (FP6) LSHM_CT_2006_037197 UK Research & Innovation (UKRI) Medical Research Council UK (MRC) MC_ UU_12015/1 MC_UU_12015/5 Danish Cancer Society Ligue Contre le Cancer (France) Institut Gustave Roussy (France) Mutuelle Generale de l'Education Nationale (France) Institut National de la Sante et de la Recherche Medicale (Inserm) Deutsche Krebshilfe Federal Ministry of Education & Research (BMBF) Deutsches Krebsforschungszentrum (Germany) Ministry of Health and Social Solidarity (Greece) Stavros Niarchos Foundation (Greece) Hellenic Health Foundation (Greece) Fondazione AIRC per la ricerca sul cancro Consiglio Nazionale delle Ricerche (CNR) MIUR "Dipartimenti di Eccellenza" D15D18000410001 Dutch Ministry of Public Health, Welfare and Sports LK Research Funds Dutch Prevention Funds Netherlands Organization for Scientific Research (NWO) World Cancer Research Fund International (WCRF) ERC-2009-AdG 232997 Nordforsk, Nordic Centre of Excellence programme on Food, Nutrition and Health (Norway) Instituto de Salud Carlos III Junta de Andalucia Principality of Asturias Regional Government of Basque Country (Spain) Regional Government of Murcia (Spain) Regional Government of Navarra (Spain) Instituto de Salud Carlos III RD06/0020 Swedish Cancer Society Swedish Scientific Council (Sweden) Regional Government of Skane and Vasterbotten (Sweden) Cancer Research UK UK Research & Innovation (UKRI) Medical Research Council UK (MRC) Leipzig Research Center for Civilization Diseases (LIFE) European Commission Free State of Saxony Netherlands Heart Foundation 2013T083 Medical Research Council UK (MRC) MR/P014550/1 Sir Henry Dale Fellowship - Welcome Trust 204623/Z/16/Z Sir Henry Dale Fellowship - Royal Society 204623/Z/16/Z |
| وصف الملف: | application/pdf |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7706a38294a047f81cbc35eb85ed4236Test https://www.repository.cam.ac.uk/handle/1810/336942Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....7706a38294a047f81cbc35eb85ed4236 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |