دورية أكاديمية
PRP-19, a conserved pre-mRNA processing factor and E3 ubiquitin ligase, inhibits the nuclear accumulation of GLP-1/Notch intracellular domain
| العنوان: | PRP-19, a conserved pre-mRNA processing factor and E3 ubiquitin ligase, inhibits the nuclear accumulation of GLP-1/Notch intracellular domain |
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| المؤلفون: | Gutnik, Silvia, Thomas, Yann, Guo, Yanwu, Stoecklin, Janosch, Neagu, Anca, Pintard, Lionel, Merlet, Jorge, Ciosk, Rafal |
| بيانات النشر: | The Company of Biologists Ltd |
| سنة النشر: | 2018 |
| المجموعة: | HighWire Press (Stanford University) |
| مصطلحات موضوعية: | RESEARCH ARTICLE |
| الوصف: | The Notch signalling pathway is a conserved and widespread signalling paradigm, and its misregulation has been implicated in numerous disorders, including cancer. The output of Notch signalling depends on the nuclear accumulation of the Notch receptor intracellular domain (ICD). Using the Caenorhabditis elegans germline, where GLP-1/Notch-mediated signalling is essential for maintaining stem cells, we monitored GLP-1 in vivo . We found that the nuclear enrichment of GLP-1 ICD is dynamic: while the ICD is enriched in germ cell nuclei during larval development, it is depleted from the nuclei in adult germlines. We found that this pattern depends on the ubiquitin proteolytic system and the splicing machinery and, identified the splicing factor PRP-19 as a candidate E3 ubiquitin ligase required for the nuclear depletion of GLP-1 ICD. |
| نوع الوثيقة: | text |
| وصف الملف: | text/html |
| اللغة: | English |
| العلاقة: | http://bio.biologists.org/cgi/content/short/7/7/bio034066Test; http://dx.doi.org/10.1242/bio.034066Test |
| DOI: | 10.1242/bio.034066 |
| الإتاحة: | https://doi.org/10.1242/bio.034066Test http://bio.biologists.org/cgi/content/short/7/7/bio034066Test |
| حقوق: | Copyright (C) 2018, Company of Biologists |
| رقم الانضمام: | edsbas.7C53BFB5 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1242/bio.034066 |
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