HPV, hypoxia and radiation response in head and neck cancer
| العنوان: | HPV, hypoxia and radiation response in head and neck cancer |
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| المؤلفون: | Ester M. Hammond, Jan Bussink, Paul N. Span, Eva-Leonne Göttgens, C. Ostheimer |
| المصدر: | British Journal of Radiology, 92, 1-10 British Journal of Radiology, 92, 1093, pp. 1-10 |
| بيانات النشر: | The British Institute of Radiology., 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Oncology, Male, medicine.medical_specialty, medicine.medical_treatment, Disease, Radiation Tolerance, Risk Assessment, 03 medical and health sciences, 0302 clinical medicine, Radiation sensitivity, Internal medicine, medicine, Carcinoma, Humans, Radiology, Nuclear Medicine and imaging, Survival analysis, Women's cancers Radboud Institute for Molecular Life Sciences [Radboudumc 17], Radiotherapy, business.industry, Squamous Cell Carcinoma of Head and Neck, Head and neck cancer, Papillomavirus Infections, HPV infection, Pushing the frontiers of radiobiology: A special feature in memory of Sir Oliver Scott and Professor Jack Fowler: Review Article, virus diseases, Dose-Response Relationship, Radiation, Radiotherapy Dosage, General Medicine, Chemoradiotherapy, Hypoxia (medical), medicine.disease, Prognosis, Survival Analysis, female genital diseases and pregnancy complications, Radiation therapy, 030104 developmental biology, Treatment Outcome, Head and Neck Neoplasms, 030220 oncology & carcinogenesis, Tumor Hypoxia, Female, medicine.symptom, business, Rare cancers Radboud Institute for Health Sciences [Radboudumc 9] |
| الوصف: | Over the last decades, the incidence of human papilloma virus (HPV) positive head and neck squamous-cell carcinoma (HNSCC) has significantly increased. Infection with high-risk HPV types drives tumourigenesis through expression of the oncoproteins E6 and E7. Currently, the primary treatment of HNSCC consists of radiotherapy, often combined with platinum-based chemotherapeutics. One of the common features of HNSCC is the occurrence of tumour hypoxia, which impairs the efficacy of radiotherapy and is a negative prognostic factor. Therefore, it is important to detect and quantify the severity of hypoxia, as well as develop strategies to specifically target hypoxic tumours. HPV-positive tumours are remarkably radiosensitive compared to HPV-negative tumours and consequently the HPV-positive patients have a better prognosis. This provides an opportunity to elucidate mechanisms of radiation sensitivity, which may reveal targets for improved therapy for HPV-negative head and neck cancers. In this review, we will discuss the differences between HPV-positive and HPV-negative head and neck tumours and methods of hypoxia detection and targeting in these disease types. Particular emphasis will be placed on the mechanisms by which HPV infection impacts radiosensitivity. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0007-1285 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df2a796011d7394e8c94bcf0d6a5338bTest https://europepmc.org/articles/PMC6435089Test/ |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....df2a796011d7394e8c94bcf0d6a5338b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00071285 |
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