Severe Perturbations of the Blood T Cell Repertoire in Polymyositis, But Not Dermatomyositis Patients
| العنوان: | Severe Perturbations of the Blood T Cell Repertoire in Polymyositis, But Not Dermatomyositis Patients |
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| المؤلفون: | Serge Herson, Luc Mouthon, David Klatzmann, Patrick Cherin, Olivier Chosidow, Thierry Maisonobe, Loïc Guillevin, Antoine Flahault, Olivier Boyer, Rastine Merat, Olivier Benveniste, Marie-Christine Burland |
| المصدر: | Journal of Immunology, Vol. 167, No 6 (2001) pp. 3521-9 |
| بيانات النشر: | The American Association of Immunologists, 2001. |
| سنة النشر: | 2001 |
| مصطلحات موضوعية: | Male, Pathology, Receptors, Antigen, T-Cell, alpha-beta, Cell Separation, CD8-Positive T-Lymphocytes, Lymphocyte Count, Polymyositis, Pathogenesis, Recurrence, T-Lymphocyte Subsets, Immunology and Allergy, Receptors, Antigen, T-Cell, alpha-beta/*chemistry, Complementarity Determining Regions/*analysis, Aged, 80 and over, Middle Aged, Flow Cytometry, medicine.anatomical_structure, Muscle, Skeletal/immunology/pathology, CD8-Positive T-Lymphocytes/immunology/pathology, Female, medicine.symptom, Adult, medicine.medical_specialty, Autoimmune Diseases/blood/diagnosis/etiology/*immunology, T cell, Immunology, Clone Cells/pathology, Polymyositis/blood/diagnosis/etiology/*immunology, Dermatomyositis, Autoimmune Diseases, Diagnosis, Differential, Antigen, Dermatomyositis/blood/diagnosis/etiology/*immunology, medicine, Humans, Muscle, Skeletal, Aged, business.industry, Muscle weakness, medicine.disease, Complementarity Determining Regions, Clone Cells, Differential diagnosis, business, CD8 |
| الوصف: | Polymyositis and dermatomyositis are diseases characterized by muscle weakness and muscle inflammatory infiltrates. Their pathogenesis remains unclear. A central role for endomysial autoaggressive CD8+ T cells is suspected in polymyositis and for perivascular B cells in dermatomyositis. We compared the T cell repertoire of 10 polymyositis and 10 dermatomyositis patients by immunoscope, a method providing a global assessment of the T cell repertoire and a sensitive detection of clonal T cell expansions. Samples were analyzed qualitatively and quantitatively in the blood (unsorted cells and CD4+ and CD8+ cells) and in muscle infiltrates. Dramatic perturbations of the T cell repertoire were observed in the blood of polymyositis but not dermatomyositis patients (p < 0.0005), the latter being undistinguishable from controls. These perturbations were due to oligoclonal expansions of CD8+ T cells and most blood clonal expansions were also found in muscle. These results indicate that the pathogenesis of polymyositis and dermatomyositis is different and reinforce the view that polymyositis but not dermatomyositis is an autoimmune CD8+ T cell-mediated disease. Moreover, this method may be helpful for the differential diagnosis of polymyositis and dermatomyositis and for noninvasive follow-up of polymyositis patients. |
| تدمد: | 1550-6606 0022-1767 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::201ee45bc1ab2b3b87873592a2cf4e67Test https://doi.org/10.4049/jimmunol.167.6.3521Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....201ee45bc1ab2b3b87873592a2cf4e67 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15506606 00221767 |
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