Regulation of C-C chemokine production by murine T cells by CD28/B7 costimulation
| العنوان: | Regulation of C-C chemokine production by murine T cells by CD28/B7 costimulation |
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| المؤلفون: | Herold, K. C., Lu, J., Rulifson, I., Vaiva Vezys, Taub, D., Grusby, M. J., Bluestone, J. A. |
| المصدر: | Scopus-Elsevier |
| بيانات النشر: | The American Association of Immunologists, 1997. |
| سنة النشر: | 1997 |
| مصطلحات موضوعية: | Immunology, Immunology and Allergy |
| الوصف: | C-C chemokines play an important role in recruitment of T lymphocytes to inflammatory sites. T lymphocytes secrete chemokines, but the activation requirements for chemokine production by T cells are uncertain. We studied the regulation of C-C chemokine production by CD28 costimulatory signals by murine T lymphocytes. Splenocytes from BALB/c mice cultured with anti-CD3 mAb expressed macrophage-inflammatory protein (MIP)-1alpha mRNA and secreted MIP-1alpha, which was inhibited by anti-B7-1 plus anti-B7-2 mAbs. MIP-1alpha production by Ag-stimulated T cells from DO.11.10 TCR transgenic mice was augmented by anti-CD28 mAb and increased compared with DO.11.10/CD28(-/-) cells. When T cell costimulation was provided by IL-2, MIP-1alpha was not enhanced. Studies with IL-2, IL-4, STAT4, and STAT6 knock-out mice suggested that chemokine production is controlled by pathways different from those regulating T cell differentiation. Thus, CD28 costimulation may amplify an immune response by stimulating T cell survival, proliferation, and production of chemokines that recruit T cells to inflammatory sites. |
| تدمد: | 1550-6606 0022-1767 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c4a6fdec8ce699a98d4ebb1330a9263Test https://doi.org/10.4049/jimmunol.159.9.4150Test |
| رقم الانضمام: | edsair.doi.dedup.....1c4a6fdec8ce699a98d4ebb1330a9263 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15506606 00221767 |
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