IFN-γ and STAT1 Arrest Monocyte Migration and Modulate RAC/CDC42 Pathways
| العنوان: | IFN-γ and STAT1 Arrest Monocyte Migration and Modulate RAC/CDC42 Pathways |
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| المؤلفون: | Yang Hu, Lionel B. Ivashkiv, Xiaoyu Hu, Laurence Boumsell |
| المصدر: | The Journal of Immunology. 180:8057-8065 |
| بيانات النشر: | The American Association of Immunologists, 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | Monocyte chemotaxis, Monocyte, Immunology, Cell Migration Inhibition, Cell migration, CDC42, Biology, Actin cytoskeleton, Cell biology, Rac GTP-Binding Proteins, Crosstalk (biology), medicine.anatomical_structure, medicine, Immunology and Allergy |
| الوصف: | Positive regulation of cell migration by chemotactic factors and downstream signaling pathways has been extensively investigated. In contrast, little is known about factors and mechanisms that induce migration arrest, a process important for retention of cells at inflammatory sites and homeostatic regulation of cell trafficking. In this study, we found that IFN-γ directly inhibited monocyte migration by suppressing remodeling of the actin cytoskeleton and cell polarization in response to the chemokine CCL2. Inhibition was dependent on STAT1 and downstream genes, whereas STAT3 promoted migration. IFN-γ altered monocyte responses to CCL2 by modulating the activity of Pyk2, JNK, and the GTPases Rac and Cdc42, and inhibiting CCL2-induced activation of the downstream p21-activated kinase that regulates the cytoskeleton and cell polarization. These results identify a new role for IFN-γ in arresting monocyte chemotaxis by a mechanism that involves modulation of cytoskeleton remodeling. Crosstalk between Jak-STAT and Rac/Cdc42 GTPase-mediated signaling pathways provides a molecular mechanism by which cytokines can regulate cell migration. |
| تدمد: | 1550-6606 0022-1767 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::a8ccf24f79ffbac94861579cacbdbc8bTest https://doi.org/10.4049/jimmunol.180.12.8057Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi...........a8ccf24f79ffbac94861579cacbdbc8b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15506606 00221767 |
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