The Tuberous Sclerosis Complex–Mammalian Target of Rapamycin Pathway Maintains the Quiescence and Survival of Naive T Cells
| العنوان: | The Tuberous Sclerosis Complex–Mammalian Target of Rapamycin Pathway Maintains the Quiescence and Survival of Naive T Cells |
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| المؤلفون: | Weiquan Li, Yang Liu, Chong Chen, Yu Liu, Tsuneo Ikenoue, Kun-Liang Guan, Yu Qiao, Pan Zheng, Chi-Shan Li, Qi Wu |
| المصدر: | The Journal of Immunology. 187:1106-1112 |
| بيانات النشر: | The American Association of Immunologists, 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | congenital, hereditary, and neonatal diseases and abnormalities, Cell type, Cell Survival, Immunology, CD4-CD8 Ratio, Mice, Transgenic, Stimulation, Biology, Resting Phase, Cell Cycle, Tuberous Sclerosis Complex 1 Protein, Article, Mice, Antigen, T-Lymphocyte Subsets, Lymphopenia, medicine, Animals, Immunology and Allergy, Cells, Cultured, Mice, Knockout, Cell growth, TOR Serine-Threonine Kinases, Tumor Suppressor Proteins, Cell biology, Mice, Inbred C57BL, medicine.anatomical_structure, Apoptosis, Gene Targeting, TSC1, Immunologic Memory, CD8, Signal Transduction |
| الوصف: | Naive T cells receive stimulation from the positive selecting ligand in the periphery for their survival. This stimulation does not normally lead to overt activation of T cells, as the T cells remain largely quiescent until they receive either antigenic or lymphopenic stimuli. The underlying mechanism responsible for survival and quiescence of the naive T cells remains largely unknown. In this study, we report that T cell-specific deletion of Tsc1, a negative regulator of mammalian target of rapamycin, resulted in both spontaneous losses of quiescence and cellularity, especially within the CD8 subset. The Tsc1-deficient T cells have increased cell proliferation and apoptosis. Tsc1 deletion affects the survival and quiescence of T cells in the absence of antigenic stimulation. Loss of quiescence but not cellularity was inhibited by rapamycin. Our data demonstrate that tuberous sclerosis complex–mammalian target of rapamycin maintains quiescence and survival of T cells. |
| تدمد: | 1550-6606 0022-1767 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e301688a30fc5b48425515c94873833Test https://doi.org/10.4049/jimmunol.1003968Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....7e301688a30fc5b48425515c94873833 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15506606 00221767 |
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