التفاصيل البيبلوغرافية
| العنوان: |
Cardiac Autotransplantation for Malignant or Complex Primary Left-Heart Tumors. |
| المؤلفون: |
Blackmon, Shanda H.1, Patel, Ashish R.2, Bruckner, Brian A.2, Beyer, Erik A.2, Rice, David C.3, Vaporciyan, Ara A.3, Wojciechowski, Zbigniew4, Correa, Arlene M.3, Reardon, Michael J.2 MReardon@tmhs.org |
| المصدر: |
Texas Heart Institute Journal. 2008, Vol. 35 Issue 3, p296-300. 5p. 2 Charts, 2 Graphs. |
| مصطلحات موضوعية: |
*HEART transplantation, *AUTOTRANSPLANTATION, *HEART tumors, *SURGICAL excision, *DRUG therapy, *CANCER relapse |
| مستخلص: |
Malignant or complex benign tumors of the left heart can present a formidable challenge for complete resection, due to anatomic inaccessibility. Cardiac autotransplantation (cardiac explantation, ex-vivo tumor resection, reconstruction, and reimplantation) was introduced for complex benign primary left-heart cardiac tumors by Cooley and for malignant left-heart tumors by Reardon. Herein, we update our previously reported experience. From April 1998 through July 2008, 20 patients underwent 21 cardiac autotransplantations for complex left-sided cardiac tumors that were nonresectable by traditional means. Demographics, tumor histology, operative data, and mortality rates were analyzed. Follow-up was complete in all patients. Of the 20 patients, 17 had malignant lesions, and 3 had benign disease. Two patients had left ventricular lesions and the rest had left atrial lesions. Histology showed 7 malignant fibrous histiocytomas, 5 undifferentiated sarcomas, 3 leiomyosarcomas, 1 malignant osteosarcoma, 1 myxoid sarcoma, 2 paragangliomas, and 1 myxoma. Fourteen patients had previous resection of their cardiac tumors, and 1 patient had repeat autotransplantation for recurrent disease. There were no operative deaths in patients undergoing autotransplantation alone (0/15), and 3 operative deaths in patients undergoing combined cardiac autotransplantation and pneumonectomy (3/6, 50%). All 3 patients with benign disease survived surgery and are alive without recurrent disease. Local recurrence occurred in 3/18 patients with malignant disease: 1 underwent successful repeat autotransplantation and 2 are receiving chemotherapy. The mean survival for all patients with sarcoma is 22 months. Cardiac autotransplantation enables complete resection and accurate reconstruction in many primary malignant and complex benign left-heart tumors. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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