دورية أكاديمية
Interferon-Gamma Gene Polymorphism +874 (A/T) in Chinese Children with Henoch-Schönlein Purpura
| العنوان: | Interferon-Gamma Gene Polymorphism +874 (A/T) in Chinese Children with Henoch-Schönlein Purpura |
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| المؤلفون: | Hui Xu, Wei Li, Haidong Fu, Guizheng Jiang |
| المصدر: | Iranian Journal of Allergy, Asthma and Immunology, Vol 13, Iss 3 (2014) |
| بيانات النشر: | Tehran University of Medical Sciences, 2014. |
| سنة النشر: | 2014 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | Cytokines, Henoch-Schonlein purpura, Interferon-gamma, Polymorphism, Susceptibility, Medicine |
| الوصف: | The aim of this study was to investigate the possible influence of Interferon-gamma (IFN- γ) gene polymorphism +874 (A/T) (rs2430561) in the susceptibility and renal complications of patients with Henoch-Schonlein purpura (HSP). We also studied the effects of IFN-γ allelic variation on serum levels of pro-and anti-inflammatory cytokines in HSP patients. The study population comprised 97 patients suffering from HSP and 97 control participants. Patients and controls were genotyped for a single nucleotide polymorphism +874 (A/T) in the first intron of the IFN-γ gene by the TaqMan PCR method. Frequencies of individuals with IFN-γ +874 AA, AT and TT genotypes were 77.3%,21.6% and 1% in HSP patients and 79.4%, 17.5% and 3.1% in controls, respectively. The frequency of the AA genotype in HSP patients with nephritis was slightly higher (83.3%) than in HSP patients without nephritis (73.8%). The allele A occurred more commonly in HSP patients with nephritis (92%) than in HSP patients without nephritis (86%), but these differences were not statistically significant (p= 0.469 and p= 0.244, respectively). In addition, significant difference in serum IL-10 levels between IFN-γ +874 different genotype groups was found. Our results do not support a role for IFN-γ gene polymorphism +874 (A/T) in the susceptibility to HSP and allelic variation at IFN-γ +874 locus had no effect on serum levels of cytokines in patients with HSP except for IL-10. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1735-1502 1735-5249 |
| العلاقة: | https://ijaai.tums.ac.ir/index.php/ijaai/article/view/458Test; https://doaj.org/toc/1735-1502Test; https://doaj.org/toc/1735-5249Test |
| الوصول الحر: | https://doaj.org/article/9a34dcd659744d8ca0b568644684eb07Test |
| رقم الانضمام: | edsdoj.9a34dcd659744d8ca0b568644684eb07 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 17351502 17355249 |
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