دورية أكاديمية
Effect of Progesterone on Expression of MMP7 and MMP13 in Lungs of Female Mice
| العنوان: | Effect of Progesterone on Expression of MMP7 and MMP13 in Lungs of Female Mice |
|---|---|
| المؤلفون: | Elahe Izadi, Fateme Vafashoar, Paria Jorbozedar, Pendar Safari, Mohamad Ali Assarehzadegan, Hadi Poormoghim, Jalil Kuhpayezadeh, Nazanin Mojtabavi |
| المصدر: | Iranian Journal of Allergy, Asthma and Immunology, Vol 17, Iss 5 (2018) |
| بيانات النشر: | Tehran University of Medical Sciences, 2018. |
| سنة النشر: | 2018 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | Collagenase, Extracellular matrix, Lung diseases, Matrilysin, Matrix metalloproteinases, Progesterone, Medicine |
| الوصف: | Gender medicine is a new era of science which focuses on the impact of sex hormones and gender on normal physiology, pathobiology and clinical features of diseases. In this study we investigated the impact of pregnancy doses of progesterone hormone on the expression of a couple of matrix metalloproteinase (MMPs), which are known to be involved in tissue remodeling of lungs in health and disease, namely MMP7 and 13. Pregnancy maintenance dose of progesterone was administered to female BALB/c mice for 21 and 28 days, the control group received PBS for the same days. After removal of the lungs and RNA extraction, quantitative real-time PCR was done using specific primers for MMP7 and MMP13. We found that progesterone can slightly (not significantly) decrease the expression of MMP13 but had no effect on MMP7. Our results shows that progesterone has minimal effect on the expression of matrix metalloproteinase7 and matrix metalloproteinase 13, but it may still have an effect on corresponding tissue inhibitor of matrix metalloproteinases (TIMPs) or other components of the Extracellular matrix which remains to be elucidated. Also, the effect of progesterone on these MMPs can be further studied in a fibrosis model. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1735-1502 1735-5249 |
| العلاقة: | https://ijaai.tums.ac.ir/index.php/ijaai/article/view/1659Test; https://doaj.org/toc/1735-1502Test; https://doaj.org/toc/1735-5249Test |
| DOI: | 10.18502/ijaai.v17i5.306 |
| الوصول الحر: | https://doaj.org/article/cc2896100a17420dbe59ba01814824d1Test |
| رقم الانضمام: | edsdoj.2896100a17420dbe59ba01814824d1 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 17351502 17355249 |
|---|---|
| DOI: | 10.18502/ijaai.v17i5.306 |