دورية أكاديمية
The role of structural proteomics in vaccine development: Recent advances and future prospects
| العنوان: | The role of structural proteomics in vaccine development: Recent advances and future prospects |
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| المؤلفون: | Donnarumma D., Faleri A, Costantino P, Rappuoli R, Norais N. |
| المساهمون: | Donnarumma, D., Faleri, A, Costantino, P, Rappuoli, R, Norais, N. |
| بيانات النشر: | Taylor and Francis Ltd |
| سنة النشر: | 2016 |
| المجموعة: | Università degli Studi di Messina: IRIS |
| مصطلحات موضوعية: | Covalent labeling, Cross-linking, Hydrogen deuterium exchange, Ion mobility, Limited proteolysi, Mass spectrometry, Structural proteomic, Vaccine, Animal, Antigen, Deuterium Exchange Measurement, Epitope Mapping, Human, Protein Conformation, Proteomic, Vaccines |
| الوصف: | Vaccines are the most effective way to fight infectious diseases saving countless lives since their introduction. Their evolution during the last century made use of the best technologies available to continuously increase their efficacy and safety. Mass spectrometry (MS) and proteomics are already playing a central role in the identification and characterization of novel antigens. Over the last years, we have been witnessing the emergence of structural proteomics in vaccinology, as a major tool for vaccine candidate discovery, antigen design and life cycle management of existing products. In this review, we describe the MS techniques associated to structural proteomics and we illustrate the contribution of structural proteomics to vaccinology discussing potential applications. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/26714563; volume:13; issue:1; firstpage:55; lastpage:68; numberofpages:14; journal:EXPERT REVIEW OF PROTEOMICS; http://hdl.handle.net/11570/3229748Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84964475979 |
| DOI: | 10.1586/14789450.2016.1121113 |
| الإتاحة: | https://doi.org/10.1586/14789450.2016.1121113Test http://hdl.handle.net/11570/3229748Test |
| رقم الانضمام: | edsbas.B860D2C9 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1586/14789450.2016.1121113 |
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