التفاصيل البيبلوغرافية
| العنوان: |
Overexpression of YPT6 restores invasive filamentous growth and secretory vesicle clustering in a Candida albicans arl1 mutant. |
| المؤلفون: |
Wakade, Rohan, Labbaoui, Hayet, Stalder, Danièle, Arkowitz, Robert A., Bassilana, Martine |
| المصدر: |
Small GTPases; May2020, Vol. 11 Issue 3, p204-210, 7p |
| مصطلحات موضوعية: |
SECRETORY granules, CANDIDA albicans, FILAMENTOUS fungi, FUNGAL virulence, FUNGAL growth, GUANOSINE triphosphatase |
| مستخلص: |
Virulence of the human fungal pathogen Candida albicans depends on the switch from budding to filamentous growth. Deletion of the Arf GTPase Arl1 results in hyphae that are shorter as well as reduced virulence. How Arl1 is regulated during hyphal growth, a process characteristic of filamentous fungi, yet absent in S. cerevisiae, is unknown. Here, we investigated the importance of the Rab6 homolog, Ypt6, in Arl1-dependent hyphal growth and determined that YPT6 overexpression specifically rescued the hyphal growth defect of an arl1 mutant, but not the converse. Furthermore, we show that deletion of ARL1 results in an alteration of the distribution of the Rab8 homolog, Sec4, in hyphal cells and that this defect is restored upon YPT6 overexpression. [ABSTRACT FROM AUTHOR] |
|
Copyright of Small GTPases is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder