التفاصيل البيبلوغرافية
| العنوان: |
Role of poorly differentiated cluster in gastric cancer: is it a new prognosis factor? |
| المؤلفون: |
Sorrentino, L., De Ruvo, N., Serra, F., Salati, M., Ricciardolo, A. A., Bonetti, L. R., Gelmini, R. |
| المصدر: |
Scandinavian Journal of Gastroenterology; Jan 2022, Vol. 57 Issue 1, p44-49, 6p |
| مصطلحات موضوعية: |
STOMACH cancer, CANCER prognosis, LYMPHATIC metastasis, GASTROINTESTINAL cancer, PROGNOSIS |
| مستخلص: |
Poorly differentiated Clusters (PDCs) of tumor cells composed of more than five elements have been recently described in gastrointestinal cancers and correlate with a worse prognosis. Our study aims to investigate PDC occurrence in a series of patients with gastric cancer and correlate it with lymph node status and clinical outcome. 50 patients were included in the study; PDCs count was graduated as G1, G2, and G3 according to Ueno classification (PDCs count at 20× <5, 5–9 and ≥10 respectively). We collected several clinicopathologic variables such as tumor location, pTNM stage, vascular or perineural invasion, and lymph-node ratio for each case. The presence of PDCs was related to vascular invasion (p <.013) and recurrence event (p <.027). When the population was categorized according to the number of PDCs, a significant correlation was found with the presence of lymph node metastasis (p <.000), the Lymph Node Ratio (p <.002), WHO stage at the diagnosis (p <.000) and vascular invasion (p <.001). At the univariate and multivariate analysis, PDCs were found as an independent risk factor for recurrence (HR 1.94; CI 95% 1.209–3.121; p <.006 and HR 0.401; CI 95% 0.187–0.862; p <.017 respectively). The Kaplan–Meier curves for OS and DFS showed a significant association between PDCs and shorter time to recurrence or survival. PDC is a strong prognostic factor in gastric cancer, easily detectable, and feasible. As far as we know, this is the first report in Literature of a strong correlation between PDC and survival in patients with operated gastric cancer. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
