التفاصيل البيبلوغرافية
| العنوان: |
Development of a pharmacogenetic-based warfarin dosing algorithm and its performance in Brazilian patients: highlighting the importance of population-specific calibration. |
| المؤلفون: |
Santos, Paulo Caleb Junior Lima, Marcatto, Leiliane Rodrigues, Duarte, Nubia Esteban, Gadi Soares, Renata Alonso, Cassaro Strunz, Celia Maria, Scanavacca, Maurício, Krieger, Jose Eduardo, Pereira, Alexandre Costa |
| المصدر: |
Pharmacogenomics; Jun2015, Vol. 16 Issue 8, p865-876, 12p |
| مستخلص: |
Background: The main aims of the present study were to develop a pharmacogenetic-based warfarin dosing algorithm and to validate it in a highly admixed population. Materials & methods: We included two patient cohorts treated with warfarin (first cohort, n = 832; and second cohort, n = 133). Results: Our algorithm achieved a determination coefficient of 40% including the variables age, gender, weight, height, self-declared race, amiodarone use, enzyme inducers use, VKORC1 genotypes and predicted phenotypes according to CYP2C9 polymorphisms. Conclusion: Data suggest that our developed algorithm is more accurate than the IWPC algorithm when the application is focused on patients from the Brazilian population. Population-specific derivation and/or calibration of warfarin dosing algorithms may lead to improved performance compared with general use dosing algorithms currently available. Original submitted 26 November 2014; Revision submitted 9 April 2015 [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
