التفاصيل البيبلوغرافية
| العنوان: |
Early Childhood Obesity is Associated With Compromised Cerebellar Development. |
| المؤلفون: |
Miller, JenniferL., Couch, Jessica, Schwenk, Krista, Long, Michelle, Towler, Stephen, Theriaque, DouglasW., He, Guojun, Liu, Yijun, Driscoll, DanielJ., Leonard, ChristianaM. |
| المصدر: |
Developmental Neuropsychology; 2009, Vol. 34 Issue 3, p272-283, 12p, 2 Charts, 4 Graphs |
| مصطلحات موضوعية: |
CHILDHOOD obesity, PRADER-Willi syndrome, GENOMIC imprinting, CEREBELLUM, ETIOLOGY of diseases, COGNITIVE development, MAGNETIC resonance imaging |
| مستخلص: |
As part of a study investigating commonalities between Prader-Willi syndrome (PWS—a genetic imprinting disorder) and early-onset obesity of unknown etiology (EMO) we measured total cerebral and cerebellar volume on volumetric magnetic resonance imaging (MRI) images. Individuals with PWS (n = 16) and EMO (n = 12) had smaller cerebellar volumes than a control group of 15 siblings (p = .02 control vs. EMO; p = .0005 control vs. PWS), although there was no difference among the groups in cerebral volume. Individuals with PWS and EMO also had impaired cognitive function: general intellectual ability (GIA): PWS 65 ± 25; EMO 81 ± 19; and Controls 112 ± 13 (p < .0001 controls vs. PWS and controls vs. EMO). As both conditions are characterized by early-onset obesity and slowed cognitive development, these results raise the possibility that early childhood obesity retards both cerebellar and cognitive development. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
