التفاصيل البيبلوغرافية
| العنوان: |
Cytotoxicity of 1-octyl-3-methylimidazolium chloride on Escherichia coli DH5α. |
| المؤلفون: |
Jing, Changqin, Hu, Huanhuan, Guo, Menglong, Chen, Xu, Li, Tianhan |
| المصدر: |
Toxin Reviews; Sep2014, Vol. 33 Issue 3, p91-94, 4p |
| مصطلحات موضوعية: |
CELL-mediated cytotoxicity, IMIDAZOLES, ESCHERICHIA coli, BACTERIAL cells, IONIC liquids, DEHYDROGENASES, CELL permeability |
| مستخلص: |
The mechanisms of the cytotoxic effect of ionic liquid (IL) 1-octyl-3-methylimidazolium chloride ([C8mim][Cl]) on bacterial cells were studied. Bacterial cells were exposed to 0, 0.1, 1 and 10 mmol ċ L−1 [C8mim][Cl] for 10 h. The results showed that [C8mim][Cl] inhibited bacterial cell proliferation in a dose-dependent manner. When IL concentrations reached 10 mmolċL−1, almost no cell division was observed. [C8mim][Cl] treatment significantly reduced succinate dehydrogenase activity. The amount of total protein significantly decreased with increasing [C8mim][Cl] concentrations of up to 10 mmolċL−1. [C8mim][Cl] increased protein and nucleic acid contents in the extracellular fluid and increased cell permeability. The results suggest that the increase in cell membrane permeability, which was induced by [C8mim][Cl], could inhibit cell proliferation and metabolic activity in bacteria. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
