التفاصيل البيبلوغرافية
| العنوان: |
Epidemiology, characterization, and diagnosis of neuropsychiatric events in systemic lupus erythematosus. |
| المؤلفون: |
de Amorim, Jaqueline Cristina, Frittoli, Renan Bazuco, Pereira, Danilo, Postal, Mariana, Dertkigil, Sergio San Juan, Reis, Fabiano, Costallat, Lilian TL, Appenzeller, Simone |
| المصدر: |
Expert Review of Clinical Immunology; Apr2019, Vol. 15 Issue 4, p407-416, 10p |
| مصطلحات موضوعية: |
SYSTEMIC lupus erythematosus, EPIDEMIOLOGY, DIAGNOSIS, LITERATURE reviews, AUTOANTIBODIES, DISEASE risk factors |
| مستخلص: |
Introduction: Neuropsychiatric systemic lupus erythematosus (NPSLE) is characterized by a heterogeneity of clinical manifestations. The absence of diagnostic criteria and the lack of clinical trials is a challenge in clinical practice. Areas covered: A literature review was performed to describe epidemiology, characterization (clinical, immunological, and imaging), diagnosis and treatment of NPSLE. Classification criteria have been the first step towards a uniform definition. More recently, different attribution models have been developed to help to determine if the NP event is due to SLE. Disease activity is a major risk factor for NP events. Cytokines and autoantibodies are associated with NP events, however, only a few studies have identified risk factors for individual NP events. Expert opinion: Further research needs to search for and validate biomarkers for NPSLE and individual NP events, including neuroimaging findings, attribution models, and serologic markers. This will be a fundamental step in planning randomized control trials in the treatment of NPSLE to improve outcome. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
