التفاصيل البيبلوغرافية
| العنوان: |
Serum Vascular Endothelial Growth Factor (VEGF) Levels Correlate with Tumor VEGF and p53 Overexpression in Endocrine Positive Primary Breast Cancer. |
| المؤلفون: |
Iovino, F., Ferraraccio, F., Orditura, M., Antoniol, G., Morgillo, F., Cascone, T., Diadema, M. R., Aurilio, G., Santabarbara, G., Ruggiero, R., Belli, C., Irlandese, E., Fasano, M., Ciardiello, F., Procaccini, E., Lo Schiavo, F., Catalano, G., De Vita, F. |
| المصدر: |
Cancer Investigation; May2008, Vol. 26 Issue 3, p250-255, 6p, 2 Charts, 1 Graph |
| مصطلحات موضوعية: |
VASCULAR endothelial growth factors, SERUM, TUMOR growth, NEOVASCULARIZATION, BREAST cancer patients |
| مستخلص: |
Vascular endothelial growth factor (VEGF) is a potent stimulator of angiogenesis, associated with unfavorable clinical characteristics in breast cancer. The aim of this study was to evaluate different angiogenic markers in endocrine-positive breast cancer patients. The authors analyzed serum and tumor samples from 71 patients with endocrine-positive operable primary breast cancer to determine the expression and the possible relationship between circulating serum VEGF levels, tumor VEGF expression, microvessel density (MVD), and other immunohistochemical parameters. Basal VEGF serum levels were significantly higher in breast cancer patients than in healthy controls. A significant correlation was observed between basal VEGF serum concentrations, microvessel density (p = 0.01) and p53 status (p = 0.004). Intratumoral VEGF expression was significantly associated with neoplastic embolization (p = 0.041) and circulating VEGF levels (p = 0.047). The results confirm that in primary endocrine-positive breast cancer serum VEGF levels are elevated and show a positive relationship with tumor VEGF and p53 overexpression. [ABSTRACT FROM AUTHOR] |
|
Copyright of Cancer Investigation is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
