التفاصيل البيبلوغرافية
| العنوان: |
Genetic variation in SLC17A7 promoter associated with response to sport-related concussions. |
| المؤلفون: |
Madura, Stephanie A., McDevitt, Jane K., Tierney, Ryan T., Mansell, Jamie L., Hayes, David J., Gaughan, John P., Krynetskiy, Evgeny |
| المصدر: |
Brain Injury; 2016, Vol. 30 Issue 7, p908-913, 6p |
| مصطلحات موضوعية: |
ATHLETES, CARRIER proteins, BRAIN concussion, CHI-squared test, CONVALESCENCE, STATISTICAL correlation, DISCRIMINANT analysis, ELECTROPHORESIS, POSTURAL balance, EXERCISE tests, FISHER exact test, GENETIC polymorphisms, ION pumps, LONGITUDINAL method, NEUROPSYCHOLOGICAL tests, MEDICAL history taking, MEMBRANE proteins, PHYSICAL diagnosis, POLYMERASE chain reaction, PROBABILITY theory, SALIVA, SCALE analysis (Psychology), SPORTS injuries, T-test (Statistics), GENETIC markers, LOGISTIC regression analysis, SEVERITY of illness index, DISEASE duration, DATA analysis software, DESCRIPTIVE statistics, GENOTYPES, ONE-way analysis of variance, SYMPTOMS, GENETICS, PROGNOSIS |
| مستخلص: |
Objective: To determine the association of the single nucleotide polymorphism (SNP) rs74174284 withinSLC17A7promoter with concussion severity or duration. Design: A between-subjects design was utilized. Methods: Saliva samples and concussion severity and duration data were collected from 40 athletes diagnosed with a sport-related concussion by a physician, utilizing a standardized concussion assessment protocol. DNA was extracted, estimated and genotyped. Results: An association was found between the dominant genetic model (CC vs GG + GC;p= 0.0179) and recovery, where those carrying the minor allele were 6.33-times more likely to experience prolonged recovery rates. Within the ImPACT assessment, those carrying the CC genotype (33.38 ± 10.15,p= 0.01) had worse motor speed scores upon initial assessment compared to both heterozygous (CG) and homozygous (GG) genotypes (41.59 ± 7.39). Conclusions: This study was the first to demonstrate an association between genetic polymorphism at rs7417284 SNP in the promoter region of theSLC17A7gene and concussion severity and duration. Based upon these findings, rs74174284 is a potential predictive genetic marker for identifying athletes who are more susceptible for altered recovery times and worse motor speed ImPACT scores after sport-related concussion. [ABSTRACT FROM PUBLISHER] |
|
Copyright of Brain Injury is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
