التفاصيل البيبلوغرافية
| العنوان: |
Tailored dose baclofen in patients with alcoholic liver disease: A case series with 2-year follow-up of hospitalisation. |
| المؤلفون: |
Heydtmann, Mathis, Macdonald, Benn, Lewsey, James, Masson, Neil, Cunningham, Leona, Irnazarow, Aleksandra, Nardone, Amanda, Cosgrave, Jan, Chick, Jonathan |
| المصدر: |
Addiction Research & Theory; Dec2015, Vol. 23 Issue 6, p510-517, 8p, 1 Black and White Photograph, 1 Diagram, 2 Charts, 3 Graphs |
| مصطلحات موضوعية: |
ALCOHOLIC liver diseases, CONFIDENCE intervals, DOSE-effect relationship in pharmacology, HOSPITAL care, LENGTH of stay in hospitals, CIRRHOSIS of the liver, LONGITUDINAL method, PROBABILITY theory, PSYCHOLOGICAL tests, QUESTIONNAIRES, RESEARCH funding, STATISTICS, DATA analysis, TREATMENT effectiveness, DATA analysis software, BACLOFEN, DESCRIPTIVE statistics |
| مصطلحات جغرافية: |
UNITED Kingdom |
| مستخلص: |
Introduction: Alcohol addiction is a major health burden with its consequences including liver disease and frequent hospitalisations. We used tailored-dose baclofen in patients with alcoholic liver disease and investigated hospital re-admissions before and after baclofen dose was initiated as well as tolerability and patient-reported alcohol consumption.Methods: Fifty-three hospitalised patients with alcoholic liver disease started tailored dose baclofen (median: 5.05 months, median highest dose before tapering down: 60 mg). Patients were followed-up for hospitalisation data from the health board database (mean hospitalisation follow up: 31 months) and patients were sent standardized questionnaires.Results: Baclofen was generally well tolerated with dose reductions in four patients. In the 2 years after initiation of the treatment, patients spent on an average of 19.1 d in the hospital per year compared to 25.48 d before the treatment initiation (p = 0.59). Respondents (19 patients) reported a reduction in alcohol consumption by an average of 58.7% (240.1 g to 144.09 g).Conclusions: After initiation of the baclofen treatment, there was a trend towards decrease in hospitalisations and in patients who answered the questionnaire, alcohol consumption decreased. [ABSTRACT FROM AUTHOR] |
|
Copyright of Addiction Research & Theory is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
