التفاصيل البيبلوغرافية
| العنوان: |
Similarities and Differences in Semantic and Phonological Processingwith Age Patterns of Functional MRI Activation. |
| المؤلفون: |
Johnson, Sterling C., Saykin, Andrew J., Flashman, Laura A., McAllister, Thomas W., O’Jile, Judith R., Sparling, Molly B., Guerin, Stephen J., Moritz, Chad H., Mamourian, Alexander C. |
| المصدر: |
Aging, Neuropsychology & Cognition; Dec2001, Vol. 8 Issue 4, p307, 14p, 1 Black and White Photograph, 3 Diagrams, 6 Charts |
| مصطلحات موضوعية: |
AGE & intelligence, MAGNETIC resonance |
| مستخلص: |
In this investigation, we analyzed the effect of age on fMRI activationduring semantic and phonological decision tasks using wholebrain echoplanarimaging Nine righthanded healthy younger adults were compared to nine righthandedhealthy older adult volunteers While undergoing fMRI scanning, subjects completedthree functional MRI auditory stimulation tasks requiring semantic or phonologicaldecisions (match/mismatch) about word pairs (category-exemplar, category-function,pseudo-word) Performance scores on these tasks did not differ between agegroups The fMRI images were motion corrected, spatially normalized, and statisticallyanalyzed for group similarities and differences using a randomeffects modelFor the semantic tasks, both older and younger adults showed activity withinthe inferior frontal gyrus (left more than right) and left superior temporalgyrus, whereas small regional age differences (younger > older)were found in the left inferior precentral region For the phonologic task,common areas of activation were found in the superior temporal gyrus (leftmore than right) Agerelated differences in the phonologic task were observedpredominantly in the right angular region The results were not changed byentry of a quantitative atrophy index as a covariate These findings highlightthe similarities in semantic processing across age groups and suggest thatglobal age related atrophy is not impacting activation significantly in healthyolder adults. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
