Is there a correlation between maternal serum TGF-beta 1 levels and fetal hydronephrosis?
| العنوان: | Is there a correlation between maternal serum TGF-beta 1 levels and fetal hydronephrosis? |
|---|---|
| المؤلفون: | Bircan Savran, İlay Gözükara, Sermin Tok, Ali Seven, Suna Kabil Kucur, Emel Kocak, Kadriye Beril Yüksel |
| بيانات النشر: | TAYLOR & FRANCIS LTD, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 0301 basic medicine, Adult, medicine.medical_specialty, TGF-b1, 030232 urology & nephrology, Gestational Age, Hydronephrosis, Kidney, Group A, Gastroenterology, Group B, Transforming Growth Factor beta1, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Pregnancy, Internal medicine, medicine, Humans, Kidney Pelvis, Gynecology, Fetus, business.industry, Obstetrics and Gynecology, Gestational age, Biomarker, medicine.disease, fetal hydronephrosis, Fetal Diseases, 030104 developmental biology, pregnant woman, Case-Control Studies, Pediatrics, Perinatology and Child Health, Mann–Whitney U test, Biomarker (medicine), Female, business, Biomarkers, TGF-beta 1, Transforming growth factor |
| الوصف: | WOS: 000368710600017 PubMed: 25902396 Objective: We aimed to identify a noninvasive marker for clinically significant fetal uropathies. To achieve this aim, we detected TGF (transforming growth factor)-1 serum level which rises in neonatal hydronephrosis, in pregnant patients with fetal hydronephrosis.Materials and methods: We evaluated 44 patients, all of whom were pregnant and had a gestational age between 20 and 30 weeks. Twenty-two patients had normal maternal renal ultrasound imaging and had a fetus with fetal hydronephrosis (Group A). The remaining twenty-two patients had normal maternal and fetal renal ultrasound imaging (Group B). The maternal serum levels of TGF-1 were measured with a sandwich enzyme-linked immunosorbent assay (ELISA) using a commercially available kit.Results: The median value for the study group was 55.90pg/mL (9.67574.45) and for the control group was 59.49pg/mL (12.49 +/- 402.04). There was no statistical difference in serum TGF-1 levels between the groups (p=0.769 - Mann-Whitney U test). In the study group, the diameter of the right renal pelvis was 5.7mm (5.1-8.9mm), while the diameter of left renal pelvis was 5.75mm (5.3-10.04mm).Conclusion: In our study, the circulating TGF-1 levels were not statistically different in the fetal hydronephrosis group when compared to the controls. According to our study, TGF-1 is not useful in the detection and follow-up of fetal hydronephrosis. We therefore require further studies involving larger groups with moderate or severe fetal hydronephrosis to detect the usefulness of the serum levels of TGF-1 in pregnant women with fetal hydronephrosis. |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33d19bba7f8d6f849a1c5397567afd26Test https://hdl.handle.net/20.500.12438/4036Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....33d19bba7f8d6f849a1c5397567afd26 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |