دورية أكاديمية
Combined using of paclitaxel and salinomycin active targeting nanostructured lipid carriers against non-small cell lung cancer and cancer stem cells
| العنوان: | Combined using of paclitaxel and salinomycin active targeting nanostructured lipid carriers against non-small cell lung cancer and cancer stem cells |
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| المؤلفون: | Jianwen Zhou, Mingshuang Sun, Shanshan Jin, Li Fan, Wenquan Zhu, Xiaoyu Sui, Lixin Cao, Chunrong Yang, Cuiyan Han |
| المصدر: | Drug Delivery, Vol 26, Iss 1, Pp 281-289 (2019) |
| بيانات النشر: | Taylor & Francis Group, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Therapeutics. Pharmacology |
| مصطلحات موضوعية: | nanostructured lipid carriers, salinomycin, paclitaxel, combined therapy, active targeting, Therapeutics. Pharmacology, RM1-950 |
| الوصف: | The existing of avidity cancer stem cells (CSCs) made it an optical strategy to kill cancer cells and CSCs at the same time. Here, we constructed a CSCs specific nanocarrier naming T-S-NLC using the CD133+ targeting peptide TISWPPR (TR) as the targeting moiety attached to the distal end of PEG on salinomycin (Sal) loaded nanostructured lipid carriers (NLC), its pharmaceutical characteristics proved it 128.73 ± 2.09 nm, anionic spheroid with sustained release profile. It's in vitro targeting effect in CD133+ CSCs indicated that it exhibited superior CSCs internalization over non-modified NLC or free drug. Afterwards, it was used in combination with previously designed EGFR specific A-P-NLC (AEYLR peptide-PEG-modified paclitaxel loaded NLC) to achieve the goal to kill the cancer cells and CSCs, simultaneously. The in vitro tumor targeting effect of T-S-NLC + A-P-NLC was affirmed by cellular uptake and proliferation inhibition effect in NCI-H1299 and S180 cell lines showing advanced results over single preparation groups. In vivo tumor targeting effect in S180 tumor-bearing mice also validated the better tumor accumulative effect of the combined group. Last but not least, the in vivo antitumor effect strongly identified the greater tumor suppression effect of T-S-NLC + A-P-NLC than single preparation groups or combined use of free drugs while maintaining a good living state of the mice. To sum up, the combined usage of PTX and Sal active targeting NLC naming A-P-NLC + T-S-NLC which killed cancer cells and CSCs at the same time was a promising drug delivery system. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1071-7544 1521-0464 10717544 |
| العلاقة: | https://doaj.org/toc/1071-7544Test; https://doaj.org/toc/1521-0464Test |
| DOI: | 10.1080/10717544.2019.1580799 |
| الوصول الحر: | https://doaj.org/article/6947343fa98e4b3189302da8b8eab584Test |
| رقم الانضمام: | edsdoj.6947343fa98e4b3189302da8b8eab584 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 10717544 15210464 |
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| DOI: | 10.1080/10717544.2019.1580799 |