دورية أكاديمية
Minthostachys verticillata essential oils as potential phytogenic additives and chemoprotective strategy on aflatoxin B1 toxicity
| العنوان: | Minthostachys verticillata essential oils as potential phytogenic additives and chemoprotective strategy on aflatoxin B1 toxicity |
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| المؤلفون: | Franco Matías Escobar, Alejandra Magnoli, María Carola Sabini, Laura Noelia Cariddi, Guillermo Bagnis, Arnaldo Soltermann, Lilia Cavaglieri |
| المصدر: | Journal of Applied Animal Research, Vol 47, Iss 1, Pp 217-222 (2019) |
| بيانات النشر: | Taylor & Francis Group, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Veterinary medicine |
| مصطلحات موضوعية: | minthostachys verticillata, essential oil, aflatoxins, cytotoxicity, genotoxicity, phytogenic feed additive, Veterinary medicine, SF600-1100 |
| الوصف: | The aim of the current study was to evaluate the protective effects of Minthostachys verticillata essential oil (Mv-EO) against aflatoxin B1-induced toxicity in Vero cells in vitro and in male rats. The cytotoxicity of AFB1 (0-30 µg/mL) and Mv-EO (0-500 µg/mL) was determined on Vero cells using the Neutral Red assays. The tested Mv-EO did not cause genotoxicity or cytotoxicity in vivo and was able to attenuate AFB1-caused cytotoxicity and genotoxicity. Animals were divided into four groups consisting of 5 (five) rats in each group: T1 basal feed (BF – negative control), T2 BF + Mv-EO [0.04%], T3 BF + AFB1 [100 µg/kg], T4 BF + food with AFB1 [100 µg/kg] + Mv-EO [0.04%]. Tissue samples were collected at the end of treatment period for genotoxic study and histological examination. Treatment with Mv-EO alone and even combined with AFB1 showed a significant improvement in the histomorphometry of intestinal villi, without alteration of productive parameters. Also, the micronucleus test demonstrated that Mv-EO reduced AFB1-induced DNA damage on bone marrow cells of male Wistar rats. This study demonstrated that Mv-EO could be used as protective against AFB1-induced cytotoxicity and genotoxicity, and as phytogenic feed additive. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0971-2119 0974-1844 09712119 |
| العلاقة: | https://doaj.org/toc/0971-2119Test; https://doaj.org/toc/0974-1844Test |
| DOI: | 10.1080/09712119.2019.1614929 |
| الوصول الحر: | https://doaj.org/article/93a2485d6bff446b8c310d709976ca2bTest |
| رقم الانضمام: | edsdoj.93a2485d6bff446b8c310d709976ca2b |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 09712119 09741844 |
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| DOI: | 10.1080/09712119.2019.1614929 |