دورية أكاديمية
Direct pro-apoptotic role for NPM1 as a regulator of PIDDosome formation
| العنوان: | Direct pro-apoptotic role for NPM1 as a regulator of PIDDosome formation |
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| المؤلفون: | Samuel Sidi, Lisa Bouchier-Hayes |
| المصدر: | Molecular & Cellular Oncology, Vol 4, Iss 5 (2017) |
| بيانات النشر: | Taylor & Francis Group, 2017. |
| سنة النشر: | 2017 |
| المجموعة: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | apoptosis, caspase-2, dna damage, npm1, nucleolus, pidd, piddosome, raidd, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Despite being frequently mutated or deregulated in acute myeloid leukemia (AML) and many other cancers, the mechanisms by which nucleophosmin (NPM1) regulates oncogenesis remain elusive. We found that NPM1 plays a direct and conserved role in DNA damage-induced assembly of the PIDDosome complex, the activating platform for caspase-2. This function is carried in the nucleolus and is essential for caspase-2-mediated apoptosis in response to a variety of DNA injuries. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2372-3556 23723556 |
| العلاقة: | https://doaj.org/toc/2372-3556Test |
| DOI: | 10.1080/23723556.2017.1348325 |
| الوصول الحر: | https://doaj.org/article/99997e69800f4c1dacd7fa9ad5a9df3bTest |
| رقم الانضمام: | edsdoj.99997e69800f4c1dacd7fa9ad5a9df3b |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 23723556 |
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| DOI: | 10.1080/23723556.2017.1348325 |