دورية أكاديمية
Impact of ETNK1 somatic mutations on phosphoethanolamine synthesis, ROS production and DNA damage
| العنوان: | Impact of ETNK1 somatic mutations on phosphoethanolamine synthesis, ROS production and DNA damage |
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| المؤلفون: | Diletta Fontana, Carlo Gambacorti-Passerini, Rocco Piazza |
| المصدر: | Molecular & Cellular Oncology, Vol 8, Iss 2 (2021) |
| بيانات النشر: | Taylor & Francis Group, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | etnk1, phosphoethanolamine, mitochondria, reactive oxigen species, dna damage, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Recently we showed that Ethanolamine Kinase 1 (ETNK1) mutations cause a decreased synthesis of phosphoethanolamine, and that phosphoethanolamine is able to modulate mitochondrial activity through competition with succinate for complex II. The decreased phosphoethanolamine concentration leads to increased mitochondria activity and reactive oxygen species production, which causes the accumulation of new mutations. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2372-3556 23723556 |
| العلاقة: | https://doaj.org/toc/2372-3556Test |
| DOI: | 10.1080/23723556.2021.1877598 |
| الوصول الحر: | https://doaj.org/article/5033e7c733c14b04a7bdfa03a7dd1b4bTest |
| رقم الانضمام: | edsdoj.5033e7c733c14b04a7bdfa03a7dd1b4b |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 23723556 |
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| DOI: | 10.1080/23723556.2021.1877598 |