دورية أكاديمية
Early 2 factor (E2F) transcription factors contribute to malignant progression and have clinical prognostic value in lower-grade glioma
| العنوان: | Early 2 factor (E2F) transcription factors contribute to malignant progression and have clinical prognostic value in lower-grade glioma |
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| المؤلفون: | Haitao Luo, Chuming Tao, Xiaoyan Long, Xingen Zhu, Kai Huang |
| المصدر: | Bioengineered, Vol 12, Iss 1, Pp 7765-7779 (2021) |
| بيانات النشر: | Taylor & Francis Group |
| سنة النشر: | 2021 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | e2f transcription factors, lower-grade glioma, risk model, overall survival, gene expression profile, Biotechnology, TP248.13-248.65 |
| الوصف: | Early 2 factor (E2F) genes encoding a family of transcription factors are significantly associated with apoptosis, metabolism, and angiogenesis in several tumor types. However, the biological functions of E2F transcription factors (E2Fs) and their potential involvement in the malignancy of lower-grade glioma (LGG) remain unclear. We explored the effects of the expression of eight E2F family members on the clinical characteristics of LGG based on the Chinese Glioma Genome Atlas (CGGA), The Cancer Genome Atlas (TCGA), and GSE16011 datasets. Two LGG subgroups were identified according to the consensus clustering of the eight E2Fs. We employed the least absolute shrinkage and selection operator (LASSO) Cox regression algorithm for further functional experiments and the development of a potential risk score. Two categories of patients with LGG were identified based on the median risk scores. We then developed a nomogram based on the results of the multivariate analysis. Real-time quantitative polymerase chain reaction (RT-qPCR) and immunohistochemistry were performed to validate the bioinformatics results. Our results indicated that E2F family members were significantly involved in the malignancy of LGG and might serve as effective prognostic biomarkers of the disease. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2165-5979 2165-5987 |
| العلاقة: | http://dx.doi.org/10.1080/21655979.2021.1985340Test; https://doaj.org/toc/2165-5979Test; https://doaj.org/toc/2165-5987Test; https://doaj.org/article/f88a12ca2ab340b0b405377d849ff6daTest |
| DOI: | 10.1080/21655979.2021.1985340 |
| الإتاحة: | https://doi.org/10.1080/21655979.2021.1985340Test https://doaj.org/article/f88a12ca2ab340b0b405377d849ff6daTest |
| رقم الانضمام: | edsbas.A66D35CA |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 21655979 21655987 |
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| DOI: | 10.1080/21655979.2021.1985340 |