Long non-coding RNA LOC285194 regulates vascular smooth muscle cell apoptosis in atherosclerosis
| العنوان: | Long non-coding RNA LOC285194 regulates vascular smooth muscle cell apoptosis in atherosclerosis |
|---|---|
| المؤلفون: | Qiushi Cheng, Maoshen Zhang, Liang Ning, Dong Chen, Min Zhang |
| المصدر: | Bioengineered, Vol 11, Iss 1, Pp 53-60 (2020) Bioengineered |
| بيانات النشر: | Taylor & Francis Group, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, long non-coding rnas, Vascular smooth muscle, proliferation, Regulator, Bioengineering, Biology, migration, Applied Microbiology and Biotechnology, Muscle, Smooth, Vascular, 03 medical and health sciences, Mice, 0302 clinical medicine, Apolipoproteins E, In vivo, Cell Movement, medicine, Animals, Humans, Cell Proliferation, Neointimal hyperplasia, Mice, Knockout, Cell growth, apoptosis, General Medicine, medicine.disease, invasion, long non-coding rna loc285194, Long non-coding RNA, In vitro, 030104 developmental biology, Apoptosis, 030220 oncology & carcinogenesis, Cancer research, Female, RNA, Long Noncoding, atherosclerosis, TP248.13-248.65, Research Paper, Biotechnology |
| الوصف: | Long non-coding RNAs (lncRNAs) recently have been implicated in many biological processes and diseases. Atherosclerosis is a major risk factor for cardiovascular disease. However, the functional role of lncRNAs in atherosclerosis is largely unknown. Here we identified LOC285194 as a key regulator of cell proliferation and apoptosis during atherosclerosis. The expression of LOC285194 was dramatically down-regulated in a aortic atherosclerotic plaques of well-defined model of apolipoprotein-E knockout (ApoE−/-) mice. Moreover, we found that targeting LOC285194 results in neointimal hyperplasia in vivo in carotid artery injury model. We also showed that targeting LOC285194 promotes cell proliferation and inhibits apoptosis in vascular smooth muscle cells (VSMCs) in vitro, and vice versa. In addition, targeting LOC285194 promotes cell invasion and migration in vitro. Our studies identify LOC285194 as a novel regulator of cell proliferation and apoptosis and suggest that this lncRNA could serve as a therapeutic target to treat atherosclerosis and related cardiovascular disorders. Graphical Abstract |
| اللغة: | English |
| تدمد: | 2165-5987 2165-5979 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cf3594260b6b2edcef1496d2691cdbfTest https://doaj.org/article/6b55fd60d5a7457b90bc56bf4fbc219bTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....8cf3594260b6b2edcef1496d2691cdbf |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21655987 21655979 |
|---|