The Intertwined Life Cycles of Enterovirus and Autophagy
| العنوان: | The Intertwined Life Cycles of Enterovirus and Autophagy |
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| المؤلفون: | Honglin Luo, Yasir Mohamud |
| المصدر: | Virulence, Vol 10, Iss 1, Pp 470-480 (2019) Virulence |
| بيانات النشر: | Taylor & Francis Group, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Microbiology (medical), Autophagosome, autophagy, Immunology, secretory autophagy, autophagosome, Human pathogen, Biology, Virus Replication, medicine.disease_cause, Microbiology, lcsh:Infectious and parasitic diseases, 03 medical and health sciences, Immune system, Viral life cycle, non-lytic release, Lysosome, Enterovirus Infections, medicine, Animals, Humans, lcsh:RC109-216, Special Focus on Autophagy in host-pathogen interactions, 030304 developmental biology, immune evasion, Life Cycle Stages, 0303 health sciences, amphisome, 030306 microbiology, enterovirus, Autophagy, Neurodegeneration, virophagy, medicine.disease, 3. Good health, Infectious Diseases, medicine.anatomical_structure, Host-Pathogen Interactions, lysosome, Enterovirus, Parasitology |
| الوصف: | Enteroviruses (EVs) are the most common human pathogens worldwide. Recent international outbreaks in North America and South East Asia have emphasized the need for more effective anti-viral therapies. As obligate parasites, EVs rely on the host cellular machinery for effective viral propagation. Accumulating evidence has indicated that EVs subvert and disrupt the cellular autophagy pathway to facilitate productive infection, and consequently leading to host pathogenesis. Given that defective autophagy is a common factor in various human diseases, including neurodegeneration, cardiomyopathy, and metabolic disorders, a clear understanding of the relationship between EV infection and autophagy is warranted. In this review, we highlight recent advances in understanding the molecular mechanisms by which EVs exploit the autophagy pathway during different steps of viral life cycle, from entry, replication, and maturation to release. We also provide an overview of recent progress in EV subversion of the autophagy for immune evasion. |
| اللغة: | English |
| تدمد: | 2150-5608 2150-5594 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f08a1c2011aae98869a4e2d720e4593Test https://doaj.org/article/aa424b40ab264b2e84e7e97270d50b89Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2f08a1c2011aae98869a4e2d720e4593 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21505608 21505594 |
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