Mitofusin 2, a key coordinator between mitochondrial dynamics and innate immunity
| العنوان: | Mitofusin 2, a key coordinator between mitochondrial dynamics and innate immunity |
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| المؤلفون: | In Soo Kim, Prashanta Silwal, Eun-Kyeong Jo |
| المصدر: | Virulence, Vol 12, Iss 1, Pp 2273-2284 (2021) Virulence article-version (VoR) Version of Record |
| بيانات النشر: | Taylor & Francis Group, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Microbiology (medical), Innate immune system, Hydrolases, Immunology, Review Article, Infectious and parasitic diseases, RC109-216, Biology, Microbiology, Mitochondrial morphology, mitofusin-2, Immunity, Innate, mitochondrial dynamics, Cell biology, GTP Phosphohydrolases, Mitochondria, Mitochondrial Proteins, Mitofusin-2, Infectious Diseases, Homeostasis, Humans, Parasitology, Mitochondrial homeostasis, infections, innate immunity |
| الوصف: | Remodeling of mitochondrial dynamics and mitochondrial morphology plays a pivotal role in the maintenance of mitochondrial homeostasis in response to pathogenic attacks or stress stimuli. In addition to their role in metabolism and energy production, mitochondria participate in diverse biological functions, including innate immune responses driven by macrophages in response to infections or inflammatory stimuli. Mitofusin-2 (MFN2), a mitochondria-shaping protein regulating mitochondrial fusion and fission, plays a crucial role in linking mitochondrial function and innate immune responses. In this article, we review the role of MFN2 in the regulation of innate immune responses during viral and bacterial infections. We also summarize the current knowledge on the role of MFN2 in coordinating inflammatory, atherogenic, and fibrotic responses. MFN2-mediated crosstalk between mitochondrial dynamics and innate immune responses may determine the outcomes of pathogenic infections. |
| اللغة: | English |
| تدمد: | 2150-5608 2150-5594 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7278de8847005ce5991f1cc422d94cdcTest https://doaj.org/article/cc94989aee38476097c3932dacaee98fTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....7278de8847005ce5991f1cc422d94cdc |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21505608 21505594 |
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