Coccidioides immitis and posadasii; A review of their biology, genomics, pathogenesis, and host immunity
| العنوان: | Coccidioides immitis and posadasii; A review of their biology, genomics, pathogenesis, and host immunity |
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| المؤلفون: | Joshua Fierer, Theo N. Kirkland |
| المصدر: | Virulence, Vol 9, Iss 1, Pp 1426-1435 (2018) Virulence, vol 9, iss 1 Kirkland, Theo N; & Fierer, Joshua. (2018). Coccidioides immitis and posadasii; A review of their biology, genomics, pathogenesis, and host immunity.. Virulence, 9(1), 1426-141435. UC Office of the President: Multicampus Research Programs and Initiatives (MRPI); a funding opportunity through UC Research Initiatives (UCRI). Retrieved from: http://www.escholarship.org/uc/item/3s1157ppTest Kirkland, TN; & Fierer, J. (2018). Coccidioides immitis and posadasii; A review of their biology, genomics, pathogenesis, and host immunity. VIRULENCE, 9(1), 1426-1435. doi: 10.1080/21505594.2018.1509667. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/9wt0c0xxTest |
| بيانات النشر: | Taylor & Francis Group, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, spherule, Mice, vaccine, Medicine and Health Sciences, 2.1 Biological and endogenous factors, Aetiology, Valley Fever, Organism, Genetics, biology, Ecology, Virulence, Genomics, Valley fever, Infectious Diseases, Medical Microbiology, Host-Pathogen Interactions, Infection, Microbiology (medical), Coccidioides immitis, Virulence Factors, coccidioidomycosis, 030106 microbiology, Immunology, Fungus, Microbiology, lcsh:Infectious and parasitic diseases, Vaccine Related, 03 medical and health sciences, Rare Diseases, Biodefense, medicine, Animals, Humans, Coccidioides, lcsh:RC109-216, Genetic variability, dimorphism, genome, Prevention, Fungi, Genetic Variation, medicine.disease, biology.organism_classification, immunity, Emerging Infectious Diseases, Ecological Applications, Parasitology, Immunization, Fungal Vaccines, Transcriptome, transcriptome |
| الوصف: | Coccidioides immitis and C. posadasii are two highly pathogenic dimorphic fungal species that are endemic in the arid areas of the new world, including the region from west Texas to southern and central California in the USA that cause coccidioidomycosis (also known as Valley Fever). In highly endemic regions such as southern Arizona, up to 50% of long term residents have been infected. New information about fungal population genetics, ecology, epidemiology, and host-pathogen interactions is becoming available. However, our understanding of some aspects of coccidioidomycosis is still incomplete, including the extent of genetic variability of the fungus, the genes involved in virulence, and how the changes in gene expression during the organism's dimorphic life cycle are related to the transformation from a free-living mold to a parasitic spherule. Unfortunately, efforts to develop an effective subunit vaccine have not yet been productive, although two potential live fungus vaccines have been developed. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2150-5608 2150-5594 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4161081b5250ae2312c0d42796fd3451Test https://doaj.org/article/d303aa5739914416ac1460c5004656afTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....4161081b5250ae2312c0d42796fd3451 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21505608 21505594 |
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