دورية أكاديمية
Harnessing MerTK agonism for targeted therapeutics
| العنوان: | Harnessing MerTK agonism for targeted therapeutics |
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| المؤلفون: | Vivekananda Kedage, Diego Ellerman, Yongmei Chen, Wei-Ching Liang, Joven Borneo, Yan Wu, Minhong Yan |
| المصدر: | mAbs, Vol 12, Iss 1 (2020) |
| بيانات النشر: | Taylor & Francis Group, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Therapeutics. Pharmacology LCC:Immunologic diseases. Allergy |
| مصطلحات موضوعية: | Phagocytosis, bispecific antibody, immunologically silent, MerTK, Fcγ receptor, Therapeutics. Pharmacology, RM1-950, Immunologic diseases. Allergy, RC581-607 |
| الوصف: | Phagocytosis plays important roles both in homeostasis and under pathological conditions. Fcγ receptor-mediated phagocytosis has been exploited as an integral mechanism for antibody-based therapies. Unlike Fcγ receptor-mediated phagocytosis, MerTK-mediated phagocytic clearance is immunologically silent. Here, we describe a bispecific antibody approach to harness MerTK for targeted clearance without inducing proinflammatory cytokine release associated with Fcγ receptor engagement. We generated bispecific antibodies targeting live B cells or amyloid beta aggregates to demonstrate the feasibility and versatility of this new approach. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 19420862 1942-0870 1942-0862 |
| العلاقة: | https://doaj.org/toc/1942-0862Test; https://doaj.org/toc/1942-0870Test |
| DOI: | 10.1080/19420862.2019.1685832 |
| الوصول الحر: | https://doaj.org/article/ff1a7c53d0604dbeb931c27b4bcbd83cTest |
| رقم الانضمام: | edsdoj.ff1a7c53d0604dbeb931c27b4bcbd83c |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 19420862 19420870 |
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| DOI: | 10.1080/19420862.2019.1685832 |