دورية أكاديمية
Elevated expression of CDKN1A-interacting zinc finger protein 1 in intimal hyperplasia after endovascular arterial injury
| العنوان: | Elevated expression of CDKN1A-interacting zinc finger protein 1 in intimal hyperplasia after endovascular arterial injury |
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| المؤلفون: | Ju Han, Guangyan Xu, Qihao Dong, Guoxian Jing, Qiang Liu, Ju Liu |
| المصدر: | All Life, Vol 15, Iss 1, Pp 95-104 (2022) |
| بيانات النشر: | Taylor & Francis Group, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Biotechnology LCC:Life |
| مصطلحات موضوعية: | ciz1, p21, neointimal hyperplasia, vascular smooth muscle cell, Biotechnology, TP248.13-248.65, Life, QH501-531 |
| الوصف: | Restenosis formation is initiated from intimal hyperplasia when arterial stretch and injury exist. In this study, we examined the role of CDKN1A-interacting zinc finger protein 1 (CIZ1) in neointimal hyperplasia in injured arteries. CIZ1 protein was up-regulated, and p21Cip1/Waf1 (p21) was down-regulated in the neointimal hyperplasia from a mouse femoral artery wire-injury model. In vitro, proliferation and migration were reduced in vascular smooth muscle cells transformed with Ciz1-shRNA lentiviral particles. In addition, p21 expression is increased, and MMP9 expression is decreased in vascular smooth muscle cells with CIZ1 knockdown. These data imply that CIZ1 might be a novel repressor of neointimal lesion formation caused by interventional therapy. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2689-5307 26895293 |
| العلاقة: | https://doaj.org/toc/2689-5307Test |
| DOI: | 10.1080/26895293.2021.2024893 |
| الوصول الحر: | https://doaj.org/article/a2eeacd93e4d4b208f4e18b6abf38d14Test |
| رقم الانضمام: | edsdoj.2eeacd93e4d4b208f4e18b6abf38d14 |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 26895307 26895293 |
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| DOI: | 10.1080/26895293.2021.2024893 |