دورية أكاديمية
TBK1 directs WIPI2 against Salmonella
| العنوان: | TBK1 directs WIPI2 against Salmonella |
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| المؤلفون: | Boyle, KB, Thurston, TLM, Randow, F |
| المصدر: | 2509 ; 2508 |
| بيانات النشر: | Taylor & Francis |
| سنة النشر: | 2016 |
| المجموعة: | Imperial College London: Spiral |
| مصطلحات موضوعية: | Science & Technology, Life Sciences & Biomedicine, Cell Biology, antibacterial autophagy, NDP52, optineurin, PI(3)P, Salmonella, TBK1, WIPI, Animals, Humans, Models, Biological, Nuclear Proteins, Protein-Serine-Threonine Kinases, Salmonella typhimurium, Vacuoles, 0601 Biochemistry And Cell Biology, Biochemistry & Molecular Biology |
| الوصف: | Defense of the mammalian cell cytosol against Salmonella invasion is reliant upon capture of the infiltrating bacteria by macroautophagy (hereafter autophagy), a process controlled by the kinase TBK1. In our recent study we showed that recruitment of TBK1 activity to Salmonella stabilizes the key autophagy regulator WIPI2 on those bacteria, a novel and essential function for TBK1 in the control of the early steps of antibacterial autophagy. Substantial redundancy exists in the precise recruitment mechanism for TBK1 because engagement with any of several Salmonella-associated ‘eat-me’ signals, including host-derived glycans, and K48- and K63-linked ubiquitin chains, suffices to recruit TBK1 functionality. We therefore propose that buffering TBK1 recruitment against potential bacterial interference might be of evolutionary advantage to the host. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1554-8627 |
| العلاقة: | Autophagy; http://hdl.handle.net/10044/1/58057Test; https://dx.doi.org/10.1080/15548627.2016.1235126Test |
| DOI: | 10.1080/15548627.2016.1235126 |
| الإتاحة: | https://doi.org/10.1080/15548627.2016.1235126Test http://hdl.handle.net/10044/1/58057Test |
| حقوق: | © 2016 MRC Laboratory of Molecular Biology. Published with license by Taylor & Francis. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0Test/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted. |
| رقم الانضمام: | edsbas.F7D7800F |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 15548627 |
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| DOI: | 10.1080/15548627.2016.1235126 |