دورية أكاديمية
Evaluation of a new point-of-care testing for creatinine and urea measurement
| العنوان: | Evaluation of a new point-of-care testing for creatinine and urea measurement |
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| المؤلفون: | Bargnoux, Anne-Sophie, Kuster, Nils, Sutra, Thibault, Laroche, Laëtitia, Rodriguez, Annie, Morena, Marion, Chenine, Leila, Chalabi, Lotfi, Dupuy, Anne-Marie, Badiou, Stéphanie, Cristol, Jean-Paul |
| المساهمون: | Physiologie & médecine expérimentale du Cœur et des Muscles U 1046 (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier), Institut des Neurosciences de Montpellier (INM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM) |
| المصدر: | ISSN: 0036-5513 ; Scandinavian Journal of Clinical and Laboratory Investigation ; https://hal.science/hal-03211936Test ; Scandinavian Journal of Clinical and Laboratory Investigation, In press, 81 (4), pp.280-297. ⟨10.1080/00365513.2021.1914344⟩. |
| بيانات النشر: | HAL CCSD Taylor & Francis |
| سنة النشر: | 2021 |
| المجموعة: | Université de Montpellier: HAL |
| مصطلحات موضوعية: | Creatinine, Analytical performances, Interferences, Point-of-care testing, Urea, MESH: Aged, MESH: Artificats, MESH: Blood Gas Analysis, MESH: Creatinine, MESH: Female, MESH: Hemolysis, MESH: Male, MESH: Humans, MESH: Point-of-Care Testing, MESH: Urea, [SDV]Life Sciences [q-bio], [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| الوصف: | International audience ; Point of care testing makes it possible to obtain results in an extremely short time. Recently, radiometer has expanded the panel of tests available on its ABL90 FLEX PLUS blood gas analyzer (ABL90) by adding urea and creatinine. The aim of this study was to verify the performance of these new parameters. This included assessment of imprecision, linearity, accuracy by comparison with central laboratory standard assays and interferences. In addition, clinical utility in a dialysis center was evaluated. Within-lab coefficients of variation were close to 2%. The mean and limits of agreement (mean ± 1.96 SD) of the difference between ABL90 and Roche enzymatic assays on cobas 8000 were 0.5 (from -1.4 to 2.3) mmol/L and -0.9 (from -19.5 to 17.8) µmol/L for urea and creatinine, respectively. The ABL90 enzymatic urea and creatinine assays met the acceptance criteria based on biological variation for imprecision and showed good agreement with central laboratory. The two assays were unaffected by hematocrit variation between 20 and 70%, hemolysis and icterus interferences. It should be noted that the relationship between lab methods and ABL90 was conserved even for high pre-dialysis values allowing easy access to dialysis adequacy parameters (Kt/V) and muscle mass evaluation (creatinine index). Rapid measurement of creatinine and urea using whole blood specimens on ABL90 appears as a fast and convenient method. Analytical performances were in accordance with our expectations without any significant interferences by hemolysis or icterus. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/33908840; hal-03211936; https://hal.science/hal-03211936Test; https://hal.science/hal-03211936/documentTest; https://hal.science/hal-03211936/file/2021%20Bargnoux%20et%20al.,%20evaluation.pdfTest; PUBMED: 33908840; WOS: 000648147000001 |
| DOI: | 10.1080/00365513.2021.1914344 |
| الإتاحة: | https://doi.org/10.1080/00365513.2021.1914344Test https://hal.science/hal-03211936Test https://hal.science/hal-03211936/documentTest https://hal.science/hal-03211936/file/2021%20Bargnoux%20et%20al.,%20evaluation.pdfTest |
| حقوق: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.E8810E33 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1080/00365513.2021.1914344 |
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