المؤلفون: Pruvost, Tiphanie, Mathieu, Magali, Dubois, Steven, Maillère, Bernard, Vigne, Emmanuelle, Nozach, Hervé

المساهمون: Service d'Ingénierie Moléculaire pour la Santé (ex SIMOPRO) (SIMoS), Médicaments et Technologies pour la Santé (MTS), Université Paris-Saclay-Institut des Sciences du Vivant Frédéric JOLIOT (JOLIOT), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Paris-Saclay-Institut des Sciences du Vivant Frédéric JOLIOT (JOLIOT), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Sanofi Vitry-sur-Seine, SANOFI Recherche

المصدر: ISSN: 1942-0862.

مصطلحات موضوعية: Monoclonal antibodies deep mutational scanning yeast surface display epitope mapping cross-species reactivity LAMP-1 DMS: Deep Mutational Scanning YSD: Yeast Surface Display NGS: next-generation sequencing cryo-EM: cryogenic electron microscopy BLI: biolayer interferometry FACS: Fluorescence-activated cell sorting CDRs: complementarity-determining regions HDX-MS: Hydrogen deuterium exchange mass spectrometry RMSD: root-mean-square deviation, Monoclonal antibodies, deep mutational scanning, yeast surface display, epitope mapping, cross-species reactivity, LAMP-1 DMS: Deep Mutational Scanning YSD: Yeast Surface Display NGS: next-generation sequencing cryo-EM: cryogenic electron microscopy BLI: biolayer interferometry FACS: Fluorescence-activated cell sorting CDRs: complementarity-determining regions HDX-MS: Hydrogen deuterium exchange mass spectrometry RMSD: root-mean-square deviation, [SDV]Life Sciences [q-bio]

العلاقة: cea-03993824; https://cea.hal.science/cea-03993824Test; https://cea.hal.science/cea-03993824/documentTest; https://cea.hal.science/cea-03993824/file/KMAB-2022-0164R1_Nozach_edited%20HN.pdfTest; WOS: 000934565000001

الإتاحة: https://doi.org/10.1080/19420862.2023.2175311Test
https://cea.hal.science/cea-03993824Test
https://cea.hal.science/cea-03993824/documentTest
https://cea.hal.science/cea-03993824/file/KMAB-2022-0164R1_Nozach_edited%20HN.pdfTest

المؤلفون: Beck, Alain, Terral, Guillaume, Debaene, François, Wagner-Rousset, Elsa, Marcoux, Julien, Janin-Bussat, Marie-Claire, Colas, Olivier, Dorsselaer, Alain Van, Cianférani, Sarah

المساهمون: Centre d'Immunologie Pierre Fabre (CIPF), PIERRE FABRE, Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Département Sciences Analytiques et Interactions Ioniques et Biomoléculaires (DSA-IPHC), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Spectrométrie de Masse BioOrganique Strasbourg (LSMBO), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Institut Pluridisciplinaire Hubert Curien (IPHC)

المصدر: ISSN: 1478-9450.

مصطلحات موضوعية: Expert Review of Proteomics Antibody drug conjugate, bioanalysis, brentuximab vedotin, drug to antibody ratio, IdeS, ion mobility MS, native MS, mass spectrometry, trastuzumab emtansine Abbreviation List MS, ESI, electrospray ionization, ADC, antibody-drug-conjugate, DAR, drug-to-antibody ratio, HDX, hydrogen/deuterium exchange, BV, T-DM1, trastuzumab emtansine, HOS, higher order structure, mAb, monoclonal antibody, HER2, human epidermal growth factor receptor 2, human immunoglobilin G, IgG, UHPLC, ultra-high performance liquid chromatography

العلاقة: hal-02335539; https://hal.science/hal-02335539Test; https://hal.science/hal-02335539/documentTest; https://hal.science/hal-02335539/file/marcoux2016.pdfTest

الإتاحة: https://doi.org/10.1586/14789450.2016.1132167Test
https://hal.science/hal-02335539Test
https://hal.science/hal-02335539/documentTest
https://hal.science/hal-02335539/file/marcoux2016.pdfTest

المؤلفون: Shaolong Zhu, Cristina Lento, Derek J. Wilson, Andrew M. Macklin, Adnan Sljoka, Bin Deng, Jianrong Xu

المصدر: mAbs

مصطلحات موضوعية: 0301 basic medicine, medicine.drug_class, Monoclonal Antibody, Immunology, Allosteric regulation, Microfluidics, Microfluidic Chip, Mass spectrometry, Monoclonal antibody, Effective Mixing, 01 natural sciences, Mass Spectrometry, Biopharmaceuticals, Binding Dynamics, 03 medical and health sciences, Laminar Flow, Epitopes, Antigen, Report, medicine, Immunology and Allergy, Humans, Millisecond, Chromatography, biology, Chemistry, Myoglobin, 010401 analytical chemistry, Antibodies, Monoclonal, Deuterium Exchange Measurement, 0104 chemical sciences, Allosteric Effects, Molecular Docking Simulation, Kinetics, 030104 developmental biology, Epitope mapping, Hydrogen Deuterium Exchange, biology.protein, Biophysics, Hydrogen–deuterium exchange, Antibody, Epitope Mapping, Time-Resolved Electrospray Ionization Mass Spectrometry, Protein Binding

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d325ffb5da090892326b19cd50b58f7aTest
http://europepmc.org/articles/PMC5680795Test

المؤلفون: Mueller, Henrik, Brener, Oleksandr, Andréoletti, Olivier, Piechatzek, Timo, Willbold, Dieter, Legname, Giuseppe, Heise, Henrike

المساهمون: Forschungszentrum Jülich GmbH, Helmholtz-Gemeinschaft = Helmholtz Association, Interactions hôtes-agents pathogènes Toulouse (IHAP), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT), Scuola Internazionale Superiore di Studi Avanzati, Partenaires INRAE

المصدر: ISSN: 1933-6896.

مصطلحات موضوعية: amyloid fibril, infectious diseases, neurodegenerative diseases, solid-state NMR spectroscopy, SOLID-STATE NMR, NUCLEAR-MAGNETIC-RESONANCE, IN-VITRO, SECONDARY STRUCTURE, CROSS-POLARIZATION, atomic force microscopy, protein structure, HUMAN PRION PROTEIN, ATOMIC-FORCE MICROSCOPY, C-TERMINAL DOMAIN, MAMMALIAN PRIONS, HYDROGEN/DEUTERIUM EXCHANGE, [SDV]Life Sciences [q-bio]

العلاقة: hal-02636634; https://hal.inrae.fr/hal-02636634Test; https://hal.inrae.fr/hal-02636634/documentTest; https://hal.inrae.fr/hal-02636634/file/kprn-08-05-983754.pdfTest; PRODINRA: 295750; PUBMEDCENTRAL: PMC4601355; WOS: 000348376700004

الإتاحة: https://doi.org/10.4161/19336896.2014.983754Test
https://hal.inrae.fr/hal-02636634Test
https://hal.inrae.fr/hal-02636634/documentTest
https://hal.inrae.fr/hal-02636634/file/kprn-08-05-983754.pdfTest

المؤلفون: Michael J. Lewis, Ping Hu, Renzhe Jin, Qingrong Yan, Jingjie Mo, Izabela Sokolowska

المصدر: mAbs

مصطلحات موضوعية: 0301 basic medicine, Monoclonal antibody, Glycosylation, medicine.drug_class, Immunology, Lysine, peptide mapping, CHO Cells, 01 natural sciences, 03 medical and health sciences, Residue (chemistry), intact LC-MS, Structure-Activity Relationship, Cricetulus, Glycation, Report, medicine, Immunology and Allergy, Bioassay, Animals, Humans, antigen binding, structural and function, biology, Chemistry, Isoelectric focusing, 010401 analytical chemistry, Antibodies, Monoclonal, Deuterium Exchange Measurement, HDX MS, 0104 chemical sciences, cIEF, 030104 developmental biology, Biochemistry, biology.protein, glycation, Hydrogen–deuterium exchange, Antibody, Immunoglobulin Heavy Chains

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4c5779c5f323dd89b759023753718caTest
http://europepmc.org/articles/PMC5916557Test

المؤلفون: Lindsey N. Young, Chunmei Chang, James H. Hurley

المصدر: Autophagy, vol 15, iss 6

مصطلحات موضوعية: 0301 basic medicine, Human immunodeficiency virus (HIV), Autophagy-Related Proteins, Class iii, medicine.disease_cause, chemistry.chemical_compound, Phosphatidylinositol Phosphates, Cryoelectron microscopy, Rubicon, human immunodeficiency virus, Kinase, Intracellular Signaling Peptides and Proteins, BECN1, Cell biology, hydrogen-deuterium exchange, Tat-BECN1 peptide, Beclin-1, Protein Binding, Signal Transduction, Biochemistry & Molecular Biology, Protein subunit, 1.1 Normal biological development and functioning, Biology, Molecular Dynamics Simulation, Article, 03 medical and health sciences, Structure-Activity Relationship, Underpinning research, medicine, Autophagy, Humans, Protein Interaction Domains and Motifs, Phosphatidylinositol, nef Gene Products, Human Immunodeficiency Virus, Molecular Biology, Nef, Binding Sites, 030102 biochemistry & molecular biology, Cryoelectron Microscopy, HIV, Cell Biology, Class III Phosphatidylinositol 3-Kinases, Enzyme Activation, 030104 developmental biology, HEK293 Cells, Structural biology, chemistry, Gene Expression Regulation, Commentary, Protein Conformation, beta-Strand, Generic health relevance, Biochemistry and Cell Biology, HeLa Cells

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d562cf7d95f2845049127d809a42615Test
https://europepmc.org/articles/PMC6526823Test/

المؤلفون: Weibin Chen, William R. Alley, Jing Fang, Alain Beck, Ying Qing Yu, Catalin E. Doneanu

المصدر: mAbs

مصطلحات موضوعية: 0301 basic medicine, Glycan, Ion-mobility spectrometry, medicine.drug_class, Immunology, N-linked glycans, Mass spectrometry, Monoclonal antibody, 01 natural sciences, High-performance liquid chromatography, RapiFluor-MS, Mass Spectrometry, hydrogen deuterium exchange, 03 medical and health sciences, Biosimilar Pharmaceuticals, Liquid chromatography–mass spectrometry, Polysaccharides, Report, ion mobility spectrometry, medicine, Immunology and Allergy, Humans, Amino Acid Sequence, Host cell proteins, higher order structure, Chromatography, UPLC, biology, Chemistry, 010401 analytical chemistry, 2D-LC, Deuterium Exchange Measurement, Biosimilar, Infliximab, 0104 chemical sciences, 030104 developmental biology, biology.protein, Neuraminic Acids, QTof, HDMSE, Chromatography, Liquid

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce46905f3ba59607373140ecdbeb694fTest
http://europepmc.org/articles/PMC4968138Test

المؤلفون: Wang, Lei, Murai, Yuta, Yoshida, Takuma, Okamoto, Masashi, Masuda, Katsuyoshi, Sakihama, Yasuko, Hashidoko, Yasuyuki, Hatanaka, Yasumaru, Hashimoto, Makoto

المصدر: Bioscience Biotechnology and Biochemistry. 78(7):1129-1134

مصطلحات موضوعية: triflic acid, aromatic alpha-amino acid, cross-link, photophore, Hydrogen/deuterium exchange

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=jairo_______::6722ff487a082dfab6f5bf5ddbd38bbeTest
http://hdl.handle.net/2115/60049Test

المؤلفون: David D. Weis, Hardeep S. Samra, Ranajoy Majumdar, David B. Volkin, C. Russell Middaugh, Steven M. Bishop, Reza Esfandiary

مصطلحات موضوعية: Serum, Methionine, Chemistry, Stereochemistry, Protein Stability, Immunology, Kinetics, Size-exclusion chromatography, Mutant, Mutation, Missense, Antibodies, Monoclonal, Epitope, Protein Structure, Tertiary, chemistry.chemical_compound, Differential scanning calorimetry, Amino Acid Substitution, In vivo, Immunoglobulin G, Biophysics, Immunology and Allergy, Hydrogen–deuterium exchange, Oxidation-Reduction, Reports, Half-Life

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae7f3679d8cca0e8e07e748cebce35d0Test
https://europepmc.org/articles/PMC4623389Test/

المؤلفون: Wang, Lei, Murai, Yuta, Yoshida, Takuma, Okamoto, Masashi, Masuda, Katsuyoshi, Sakihama, Yasuko, Hashidoko, Yasuyuki, Hatanaka, Yasumaru, Hashimoto, Makoto

مصطلحات موضوعية: Hydrogen/deuterium exchange, aromatic alpha-amino acid, cross-link, photophore, triflic acid

الوقت: 464

العلاقة: http://hdl.handle.net/2115/60049Test; Bioscience Biotechnology and Biochemistry, 78(7): 1129-1134; http://dx.doi.org/10.1080/09168451.2014.917267Test

الإتاحة: https://doi.org/10.1080/09168451.2014.917267Test
http://hdl.handle.net/2115/60049Test