دورية أكاديمية
Maternal Mediterranean diet in pregnancy and newborn DNA methylation: a meta-analysis in the PACE Consortium
| العنوان: | Maternal Mediterranean diet in pregnancy and newborn DNA methylation: a meta-analysis in the PACE Consortium |
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| المؤلفون: | Küpers, Leanne K., Fernández-Barrés, Sílvia, Nounu, Aayah, Friedman, Chloe, Fore, Ruby, Mancano, Giulia, Dabelea, Dana, Rifas-Shiman, Sheryl L., Mulder, Rosa H., Oken, Emily, Johnson, Laura, Bustamante Pineda, Mariona, Jaddoe, Vincent W. V., Hivert, Marie-France, Starling, Anne P., de Vries, Jeanne H. M., Sharp, Gemma C., Vrijheid, Martine, Felix, Janine Frédérique |
| بيانات النشر: | Taylor & Francis |
| المجموعة: | UPF Digital Repository (Universitat Pompeu Fabra, Barcelona) |
| مصطلحات موضوعية: | DNA methylation, Epigenetics, Mediterranean diet, Cord blood, Epigenome-wide association study, Maternal diet, Newborn, Prenatal diet |
| الوصف: | Higher adherence to the Mediterranean diet during pregnancy is related to a lower risk of preterm birth and to better offspring cardiometabolic health. DNA methylation may be an underlying biological mechanism. We evaluated whether maternal adherence to the Mediterranean diet was associated with offspring cord blood DNA methylation.We meta-analysed epigenome-wide association studies (EWAS) of maternal adherence to the Mediterranean diet during pregnancy and offspring cord blood DNA methylation in 2802 mother-child pairs from five cohorts. We calculated the relative Mediterranean diet (rMED) score with range 0-18 and an adjusted rMED excluding alcohol (rMEDp, range 0-16). DNA methylation was measured using Illumina 450K arrays. We used robust linear regression modelling adjusted for child sex, maternal education, age, smoking, body mass index, energy intake, batch, and cell types. We performed several functional analyses and examined the persistence of differential DNA methylation into childhood (4.5-7.8 y).rMEDp was associated with cord blood DNA methylation at cg23757341 (0.064% increase in DNA methylation per 1-point increase in the rMEDp score, SE = 0.011, P = 2.41 × 10-8). This cytosine-phosphate-guanine (CpG) site maps to WNT5B, associated with adipogenesis and glycaemic phenotypes. We did not identify associations with childhood gene expression, nor did we find enriched biological pathways. The association did not persist into childhood.In this meta-analysis, maternal adherence to the Mediterranean diet (excluding alcohol) during pregnancy was associated with cord blood DNA methylation level at cg23757341. Potential mediation of DNA methylation in associations with offspring health requires further study. ; This work was supported by the Foundation for the National Institutes of Health [R01 HD034568, UH3 OD023286, R01 NR013945, R01 HL111108]; Joint Programming Initiative A healthy diet for a healthy life [529051023, MR/S036520/1, 529051022, MR/S036520/1, MR/S036520/1]; National Institute of Environmental ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1559-2294 |
| العلاقة: | Epigenetics. 2022 Nov;17(11):1419-31; info:eu-repo/grantAgreement/EC/H2020/874739; info:eu-repo/grantAgreement/EC/H2020/733206; info:eu-repo/grantAgreement/EC/H2020/848158; info:eu-repo/grantAgreement/EC/H2020/824989; Küpers LK, Fernández-Barrés S, Nounu A, Friedman C, Fore R, Mancano G, Dabelea D, Rifas-Shiman SL, Mulder RH, Oken E, Johnson L, Bustamante M, Jaddoe VWV, Hivert MF, Starling AP, de Vries JHM, Sharp GC, Vrijheid M, Felix JF. Maternal Mediterranean diet in pregnancy and newborn DNA methylation: a meta-analysis in the PACE Consortium. Epigenetics. 2022 Nov;17(11):1419-31. DOI:10.1080/15592294.2022.2038412; http://hdl.handle.net/10230/53150Test; http://dx.doi.org/10.1080/15592294.2022.2038412Test |
| DOI: | 10.1080/15592294.2022.2038412 |
| الإتاحة: | https://doi.org/10.1080/15592294.2022.2038412Test http://hdl.handle.net/10230/53150Test |
| حقوق: | © 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0Test/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. ; http://creativecommons.org/licenses/by/4.0Test/ ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.17DFA145 |
| قاعدة البيانات: | BASE |
| تدمد: | 15592294 |
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| DOI: | 10.1080/15592294.2022.2038412 |