المؤلفون: Kiani, Reza, Pouraliakbar, Hamidreza, Alemzadeh-Ansari, Mohammad Javad, Khademi, Ali, Peighambari, Mohamad Mehdi, Mohebbi, Bahram, Firouzi, Ata, Zahedmehr, Ali, Shakerian, Farshad, Hosseini, Zahra, Rashidinejad, Alireza

المصدر: Journal of Cardiovascular & Thoracic Research; 2020, Vol. 12 Issue 3, p203-208, 6p

مصطلحات موضوعية: CALCIUM metabolism, BLOOD vessels, COMPUTED tomography, CORONARY artery stenosis, CORONARY disease, MEDICAL records, NEUTROPHILS, RETROSPECTIVE studies, DESCRIPTIVE statistics, LYMPHOCYTE count, ACQUISITION of data methodology, ODDS ratio

مستخلص: Introduction: Cardiovascular diseases, including coronary artery disease (CAD), are among the most common causes of death in the elderly population. Recent studies have found that coronary artery calcium score (CACS) is a strong independent predictor of CAD. Here we aimed to investigate the association between CACS and demographic, clinical, laboratory, and CT angiographic findings in patients with suspected CAD. Methods: From June 2008 to August 2018, we retrospectively reviewed 219 consecutive patients suspected with CAD who were referred for CT angiography in Rajaie Cardiovascular, Medical, and Research Center. Medical records were reviewed, and relevant demographic, clinical, laboratory and imaging were collected. Results: A total of 219 patients with an average age of 62.64±12.39 were included. Twelve patients (5.5%) had normal coronary angiography, and 50.2% had mild CAD. An obstructive CAD was found in 97 patients (44.3%). The median CACS was 76.4 (IQR, 13.0-289.1). The frequency of obstructive CAD was 28.1% in the CACS <100 group, and 67.0% in CACS >100 group (P < 0.001). On multiple logistic regression analysis, age (OR=1.04 [1.01-1.07], P=0.006), CACS (OR= 4.31 [2.33-7.98], P < 0.001), and neutrophil to lymphocyte ratio (NLR) (OR = 0.82 [0.68-0.98], P = 0.027) were independent predictors of obstructive CAD. Conclusion: We found a direct association between higher CACS and obstructive patterns in coronary CT angiography. Our findings indicate that the possibility of the presence of obstructive CAD was higher among symptomatic patients with older age, lower NLR, and CACS >100. [ABSTRACT FROM AUTHOR]

: Copyright of Journal of Cardiovascular & Thoracic Research is the property of Tabriz University of Medical Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Firouzi, Ata, Alemzadeh-Ansari, Mohammad Javad, Mohammadhadi, Naser, Peighambari, Mohammad Mehdi, Zahedmehr, Ali, Mohebbi, Bahram, Kiani, Reza, Sanati, Hamid Reza, Shakerian, Farshad, Rashidinejad, Alireza, Ghadrdoost, Behshid, Asghari, Raana, Shokrollahi Yancheshmeh, Simin

المصدر: Journal of Cardiovascular & Thoracic Research; 2020, Vol. 12 Issue 1, p51-55, 5p

مصطلحات موضوعية: KIDNEY disease risk factors, CARDIAC catheterization, CONFIDENCE intervals, CORONARY artery bypass, CREATININE, KIDNEY diseases, MULTIVARIATE analysis, CONTRAST media, DESCRIPTIVE statistics, ODDS ratio, PERCUTANEOUS coronary intervention, DRUG administration, DRUG dosage

مستخلص: Introduction: The risk of contrast-induced nephropathy (CIN) as a common and important complication of coronary procedures may be influenced by the vascular access site. We compared the risks of CIN in diagnostic or interventional coronary management between patients treated via the transradial access (TRA) and those treated via the transfemoral access (TFA). Methods: Patients undergoing invasive coronary catheterization or percutaneous coronary intervention (PCI) were enrolled. We excluded patients with congenital or structural heart disease and those with end-stage renal disease on dialysis. Based on the vascular access site used for invasive coronary catheterization, the patients were divided into 2 study groups: the TFA and the TRA. CIN was defined as an absolute (≥0.5 mg/dL) or relative (>25%) increase in the baseline serum creatinine level within 48 hours following cardiac catheterization or PCI. Results: Overall, 410 patients (mean age = 61.3 ± 10.8 years) underwent diagnostic or interventional coronary management: 258 were treated via the TFA approach and 152 via the TRA approach. The patients treated via the TFA had a significantly higher incidence of postprocedural CIN (15.1% vs 6.6%; P = 0.01). The multivariate analysis showed that the TFA was the independent predictor of CIN (OR: 2.37, 95% CI: 1.11 to 5.10, and P = 0.027). Moreover, the BARC (Bleeding Academic Research Consortium) and Mehran scores were the other independent predictors of CIN in our study. Conclusion: The risk of CIN was lower with the TRA, and the TFA was the independent predictor of CIN after the diagnostic or interventional coronary management. [ABSTRACT FROM AUTHOR]

: Copyright of Journal of Cardiovascular & Thoracic Research is the property of Tabriz University of Medical Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Firouzi, Ata, Kazem Moussavi, Ali, Mohebbi, Ahmad, Alemzadeh-Ansari, Mohammad Javad, Kiani, Reza, Sanati, Hamid Reza, Mohebbi, Bahram, Shakerian, Farshad, Zahedmehr, Ali, Ansari-Ramandi, Mohammad Mostafa, Oni Heris, Saeed, Ghaleshi, Bahar, Ghorbani, Fatemeh

المصدر: Journal of Cardiovascular & Thoracic Research; 2018, Vol. 10 Issue 3, p149-152, 4p

مصطلحات موضوعية: KIDNEY disease prevention, PREVENTION of surgical complications, CREATININE, HEALTH facilities, HOSPITAL admission & discharge, KIDNEY diseases, MYOCARDIAL infarction, PATIENTS, STATISTICAL sampling, RANDOMIZED controlled trials, TREATMENT effectiveness, DISEASE incidence, CONTRAST media, BLIND experiment, ATORVASTATIN, PERCUTANEOUS coronary intervention, ROSUVASTATIN, THERAPEUTICS

مستخلص: Introduction: There is some controversy over the efficacy of statins for the prevention of contrastinduced nephropathy (CIN). There have also been reports on varying efficacies of different statins. Hence, in this study the efficacy of atorvastatin and rosuvastatin for the prevention of CIN was assessed. Methods: This single-blind randomized clinical trial was performed on 495 random patients with myocardial infarction with ST-segment elevation undergoing primary percutaneous coronary intervention (PCI) in a training referral hospital in 2015. Patients were randomly assigned to receive either atorvastatin 80 mg at admission and daily or rosuvastatin 40 mg at admission and daily. CIN was defined based on serum creatinine elevation after 48 hours from the PCI. Results: The incidence of CIN was observed in 63 patients (21.4%) After 48 hours from primary PCI. Of those, 17% (n = 50) were grade 1 CIN, while 4.4% (n = 13) were grade 2 CIN. There was no significant difference between rosuvastatin group compared with atorvastatin group, regarding the CIN grading (P = 0.14). Conclusion: Our results indicate that atorvastatin and rosuvastatin have similar efficacy for the prevention of CIN. [ABSTRACT FROM AUTHOR]

: Copyright of Journal of Cardiovascular & Thoracic Research is the property of Tabriz University of Medical Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)