The growth cone as seen through cajal's original histological preparations and publications
| العنوان: | The growth cone as seen through cajal's original histological preparations and publications |
|---|---|
| المؤلفون: | Virginia García-Marín, Pablo García-López, Miguel Freire |
| المصدر: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| بيانات النشر: | Swets & Zeitlinger, 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Nervous system, Silver Staining, Histology, General Neuroscience, Growth Cones, Histological Techniques, digestive, oral, and skin physiology, Target tissue, Neurophysiology, History, 19th Century, Anatomy, Biology, History, 20th Century, Golgi impregnation, medicine.anatomical_structure, History and Philosophy of Science, nervous system, Nerve cells, medicine, Animals, Neurology (clinical), Neuron, Axon, Growth cone, Neuroscience |
| الوصف: | During the development of the nervous system, each neuron must contact its appropriate target cell in order to establish its specific connections. More than a century ago, Ramon y Cajal discovered an amoeboid-like structure at the end of the axon of developing nerve cells. He called this structure the growth cone [cono de crecimiento] and he proposed that this structure was guided towards its target tissue by chemical substances secreted by the different cells that line its course. We have reviewed the discovery of the growth cone by Cajal using his original publications, his original scientific drawings, and by studying his histological preparations conserved at the Instituto Cajal (Madrid, Spain).1 We found a very good correlation between the structure of the growth cone in the Golgi-impregnated and reduced silver-nitrate-stained material used by Cajal, and that which is revealed with present-day methods. Finally, Cajal's view of the function of the growth cone and his chemotactic hypothesis will also be considered in the light of present-day knowledge. |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c26b53db92a9a1347aa8a329b9758e6eTest http://hdl.handle.net/10261/62091Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c26b53db92a9a1347aa8a329b9758e6e |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |