Human KIAA1018/FAN1 nuclease is a new mitotic substrate of APC/CCdh1
| العنوان: | Human KIAA1018/FAN1 nuclease is a new mitotic substrate of APC/CCdh1 |
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| المؤلفون: | Yuanzhong Wu, Yi Sang, Kaishun Hu, Jingying Cao, Jianjun Tang, Fenju Lai, Tiebang Kang |
| المصدر: | Chinese Journal of Cancer |
| بيانات النشر: | Sun Yat-sen University Cancer Center, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Cdc20 Proteins, Mitosis, Bone Neoplasms, Cell Cycle Proteins, CDC20, KIAA1018/FAN1, Biology, Anaphase-Promoting Complex-Cyclosome, Antigens, CD, Cell Line, Tumor, FANCD2, DNA Interstrand Crosslinking, APC/C, Humans, Nuclease, Osteosarcoma, Cdh1, Endodeoxyribonucleases, FAN1, Ubiquitin-Protein Ligase Complexes, Cell cycle, Cadherins, Molecular biology, Multifunctional Enzymes, Cell biology, Exodeoxyribonucleases, HEK293 Cells, Oncology, Mitotic exit, biology.protein, cell cycle, Original Aticle |
| الوصف: | A recently identified protein, FAN1 (FANCD2-associated nuclease 1, previously known as KIAA1018), is a novel nuclease associated with monoubiquitinated FANCD2 that is required for cellular resistance against DNA interstrand crosslinking (ICL) agents. The mechanisms of FAN1 regulation have not yet been explored. Here, we provide evidence that FAN1 is degraded during mitotic exit, suggesting that FAN1 may be a mitotic substrate of the anaphase-promoting cyclosome complex (APC/C). Indeed, Cdh1, but not Cdc20, was capable of regulating the protein level of FAN1 through the KEN box and the D-box. Moreover, the up- and down-regulation of FAN1 affected the progression to mitotic exit. Collectively, these data suggest that FAN1 may be a new mitotic substrate of APC/CCdh1 that plays a key role during mitotic exit. |
| اللغة: | English |
| تدمد: | 1944-446X 1000-467X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0f794d4acb9592813213c7a822db42dTest http://europepmc.org/articles/PMC3777502Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d0f794d4acb9592813213c7a822db42d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1944446X 1000467X |
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