دورية أكاديمية
Potent anti-tumor immunostimulatory biocompatible nanohydrogel made from DNA
| العنوان: | Potent anti-tumor immunostimulatory biocompatible nanohydrogel made from DNA |
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| المؤلفون: | Jiana Jiang, Xianming Kong, Yuexia Xie, Hanbing Zou, Qianyun Tang, Ding Ma, Xue Zhao, Xiaozhen He, Anyue Xia, Peifeng Liu |
| المصدر: | Nanoscale Research Letters, Vol 14, Iss 1, Pp 1-10 (2019) |
| بيانات النشر: | SpringerOpen, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Materials of engineering and construction. Mechanics of materials |
| مصطلحات موضوعية: | CpG, Nanohydrogel, Immunotherapy, Macrophage, Glioma, Materials of engineering and construction. Mechanics of materials, TA401-492 |
| الوصف: | Abstract Unmethylated CpG oligodeoxynucleotides are potent immunostimulatory motifs in activating both innate and acquired immune system by inducing Th1 type antigen-specific T cell responses, but their instability in serum greatly influences their immunostimulant efficiency. Here, we constructed a novel immuno-DNA nanohydrogels consisting of tandem repeat sequences of CpG units named CpG-MCA nanohydrogels through multi-primed chain amplification. CpG-MCA nanohydrogels were proved to resist degradation and increase the proliferation and migration of murine macrophage-like RAW264.7 cells. Furthermore, CpG-MCA nanohydrogels effectively induced high expression of tumor necrosis factor-α and interleukin-6, and remarkably inhibited the proliferation of U251 cells, suggesting that CpG-MCA nanohydrogels are expected to be employed as the potent anti-cancer immunostimulant. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1931-7573 1556-276X |
| العلاقة: | http://link.springer.com/article/10.1186/s11671-019-3032-9Test; https://doaj.org/toc/1931-7573Test; https://doaj.org/toc/1556-276XTest |
| DOI: | 10.1186/s11671-019-3032-9 |
| الوصول الحر: | https://doaj.org/article/cfd0b942c4804bbd948c7f668cb6922eTest |
| رقم الانضمام: | edsdoj.fd0b942c4804bbd948c7f668cb6922e |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 19317573 1556276X |
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| DOI: | 10.1186/s11671-019-3032-9 |