دورية أكاديمية
Diagnostic and prognostic value of single nucleotide polymorphisms in autophagy-related genes (ATG) among Egyptian patients with breast cancer disease
| العنوان: | Diagnostic and prognostic value of single nucleotide polymorphisms in autophagy-related genes (ATG) among Egyptian patients with breast cancer disease |
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| المؤلفون: | Sara F. Saadawy, Ahmed Raafat, Walaa E. Omar |
| المصدر: | Egyptian Journal of Medical Human Genetics, Vol 25, Iss 1, Pp 1-10 (2024) |
| بيانات النشر: | SpringerOpen, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Medicine (General) LCC:Genetics |
| مصطلحات موضوعية: | Breast cancer, ATG7, ATG10, Diagnosis, Prognosis, Single gene polymorphisms (SNPs), Medicine (General), R5-920, Genetics, QH426-470 |
| الوصف: | Abstract Background Autophagy-related genes (ATGs), associated with autophagy, contribute to the pathogenesis of many illnesses, including cancer. ATGs’ role in breast cancer (BC) is still under investigation. Therefore, the current study aimed to determine whether genetic variants in core ATGs correlate with BC prognosis and investigate their impact on protein plasma levels. Methods This case–control study was carried out on 70 BC patients as well as 70 cancer-free controls in order to determine the association of these variants with BC risk. ATG10 (rs1864182) and ATG7 (rs1375206) polymorphisms were genotyped in whole blood samples using TaqMan SNP Genotyping Assays, and ATG7 and ATG10 levels in plasma were determined using ELISA. Results The results revealed that ATG7 (rs1375206) might contribute to BC, as patients with the GG genotype displayed a substantial association with BC (OR = 3.23, 95% CI 1.12–9.5) as well as a significant increase in ATG7 protein expression. For ATG7 rs1375206, genotypes GG was significantly associated with increased BC risk; carriers of the G allele frequently have a bad prognosis compared to carriers of the CC genotype (OR of mortality equals 3.01). Serum ATG 7 in the breast cancer patients’ group was significantly higher than that in the control group (p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2090-2441 |
| العلاقة: | https://doaj.org/toc/2090-2441Test |
| DOI: | 10.1186/s43042-023-00470-6 |
| الوصول الحر: | https://doaj.org/article/57138703fa1d48dab8c1901dfc1b31beTest |
| رقم الانضمام: | edsdoj.57138703fa1d48dab8c1901dfc1b31be |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20902441 |
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| DOI: | 10.1186/s43042-023-00470-6 |