دورية أكاديمية
Prognostic biomarkers in predicting mortality in respiratory patients with ventilator-associated pneumonia
| العنوان: | Prognostic biomarkers in predicting mortality in respiratory patients with ventilator-associated pneumonia |
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| المؤلفون: | Nermeen A. Abdelaleem, Hoda A. Makhlouf, Eman M. Nagiub, Hassan A. Bayoumi |
| المصدر: | The Egyptian Journal of Bronchology, Vol 15, Iss 1, Pp 1-8 (2021) |
| بيانات النشر: | SpringerOpen, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Diseases of the respiratory system LCC:Medical emergencies. Critical care. Intensive care. First aid |
| مصطلحات موضوعية: | Red cell distribution width (RDW), Ventilator-associated pneumonia (VAP), Mortality, Neutrophil-to-lymphocyte ratio (NLR), Sequential Organ Failure Assessment (SOFA) score, Respiratory, Diseases of the respiratory system, RC705-779, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9 |
| الوصف: | Abstract Background Ventilator-associated pneumonia (VAP) is the most common nosocomial infection. Red cell distribution width (RDW) and neutrophil-lymphocyte ratio (NLR) are prognostic factors to mortality in different diseases. The aim of this study is to evaluate prognostic efficiency RDW, NLR, and the Sequential Organ Failure Assessment (SOFA) score for mortality prediction in respiratory patients with VAP. Results One hundred thirty-six patients mechanically ventilated and developed VAP were included. Clinical characteristics and SOFA score on the day of admission and at diagnosis of VAP, RDW, and NLR were assessed and correlated to mortality. The average age of patients was 58.80 ± 10.53. These variables had a good diagnostic performance for mortality prediction AUC 0.811 for SOFA at diagnosis of VAP, 0.777 for RDW, 0.728 for NLR, and 0.840 for combined of NLR and RDW. The combination of the three parameters demonstrated excellent diagnostic performance (AUC 0.889). A positive correlation was found between SOFA at diagnosis of VAP and RDW (r = 0.446, P < 0.000) and with NLR (r = 0.220, P < 0.010). Conclusions NLR and RDW are non-specific inflammatory markers that could be calculated quickly and easily via routine hemogram examination. These markers have comparable prognostic accuracy to severity scores. Consequently, RDW and NLR are simple, yet promising markers for ICU physicians in monitoring the clinical course, assessment of organ dysfunction, and predicting mortality in mechanically ventilated patients. Therefore, this study recommends the use of blood biomarkers with the one of the simplest ICU score (SOFA score) in the rapid diagnosis of critical patients as a daily works in ICU. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1687-8426 2314-8551 |
| العلاقة: | https://doaj.org/toc/1687-8426Test; https://doaj.org/toc/2314-8551Test |
| DOI: | 10.1186/s43168-021-00062-1 |
| الوصول الحر: | https://doaj.org/article/75e7067bcbe54554ad839e0b94ca0636Test |
| رقم الانضمام: | edsdoj.75e7067bcbe54554ad839e0b94ca0636 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 16878426 23148551 |
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| DOI: | 10.1186/s43168-021-00062-1 |