مورد إلكتروني
Performance of the PEdiatric Logistic Organ Dysfunction-2 score in critically ill children requiring plasma transfusions
| العنوان: | Performance of the PEdiatric Logistic Organ Dysfunction-2 score in critically ill children requiring plasma transfusions |
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| المصدر: | Annals of Intensive Care |
| بيانات النشر: | SpringerOpen 2016-12-01 |
| تفاصيل مُضافة: | Karam, Oliver Demaret, Pierre Duhamel, Alain Shefler, Alison Spinella, Philip C. Stanworth, Simon J. Tucci, Marisa Leteurtre, Stéphane Butt, Warwick Delzoppo, Carmel Bain, Kym Erickson, Simon Smalley, Nathan Dorofaeff, Tavey Long, Debbie Wiseman, Greg Clénent de Cléty, Stéphan Berghe, Caroline de Jaeger, Annick Trippaerts, Marc Willems, Ariane Rooze, Shancy De Dooy, Jozef Gilfoyle, Elaine Wohlgemuth, Lynette Dumitrascu, Mariana Withington, Davinia Hickey, Julia Choong, Karen Sanders, Lois Morrison, Gavin Tijssen, Janice Wensley, David Krahn, Gordon Dugas, Marc Andre Gosselin, Louise Santschi, Miriam Von Dessauer, Bettina Ordenes, Nadia Afshari, Arash Andersen, Lasse Hoegh Nilsson, Jens Christian Johansen, Mathias Baek Jensen, Anne Mette Campos Mino, Santiago Grunauer, Michelle Joram, Nicolas Roullet-Renoleau, Nicolas Javouhey, Etienne Cour-Andlauer, Fleur Portefaix, Aurélie Brissaud, Olivier Guichoux, Julie Payen, Valérie Léger, Pierre Louis Afanetti, Mickael Mortamet, Guillaume Maria, Matthieu Breining, Audrey Tissieres, Pierre Dorkenoo, Aimée Deho, Anna Steinherr, Harry Nikolaou, Filippia Camporesi, Anna Mario, Federica Kawasaki, Tatsuya Miura, Shinya Beca, John Rea, Miriam Sherring, Claire Bushell, Tracey Bentsen, Gunnar Dinis, Alexandra Pereira, Gabriela Vieira, Marisa Moniz, Marta Alshehri, Saleh Alasnag, Manal Pisarcikova, Maria Jordan, Iolanda Balcells, Joan Perez-Ferrer, Antonio de Vicente Sánchez, Jesús Vazquez Moyano, Marta Morales Martinez, Antonio Lopez-Herce, Jesus Solana, Maria Jose Flores González, Jose Carlos Alonso, Maria Teresa Nieto Faza, Manuel Perez, Marie Hélène Amiet, Vivianne Doell, Carsten Bordessoule, Alice Cochius-den Otter, Suzan Kapitein, Berber Kneyber, Martin Brierley, Joe Rea, Vanessa McKeever, Stephen Kelleher, Andrea Scholefield, Barney Top, Anke Kelly, Nicola Virdee, Satnam Davis, Peter George, Susan Hawkins, Kay C. McCall, Katie Brown, Victoria Sykes, Kim Levin, Richard MacLeod, Isobel Horan, Marie Jirasek, Petr Inwald, David Abdulla, Amina Raghunanan, Sophie Taylor, Bob Sparkes, Hannah Hanson, Sheila Woods, Katherine Triscari, David Murkowski, Kathy Ozment, Caroline Steiner, Marie Nerheim, Dan Galster, Amanda Higgerson, Renee Christie, Lee Ann Martin, Daniel Rourke, Liz Muszynski, Jennifer Steele, Lisa Ajizian, Samuel McCrory, Michael C. O’Brien, Kevin Babbitt, Christopher Felkel, Erin Levine, Glenn Truemper, Edward J. Zink, Machelle Nellis, Marianne Thomas, Neal J. Spear, Debbie Markovitz, Barry Terry, Jeff Morzov, Rica Montgomery, Vicki Michael, Andrew Thomas, Melissa Singleton, Marcy Jarvis, Dean Nett, Sholeen Willson, Douglas Hoot, Michelle Bembea, Melania Yiu, Alvin McKinley, David Scarlett, Elizabeth Sankey, Jennifer Parikh, Minal Vincent, E. Faustino, S. Michelson, Kelly Rilinger, Jay Campbell, Laura Gertz, Shira Cholette, Jill M. Jeyapalan, Asumthia Parker, Margaret Bateman, Scot Johnson, Amanda |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | BackgroundOrgan dysfunction scores, based on physiological parameters, have been created to describe organ failure. In a general pediatric intensive care unit (PICU) population, the PEdiatric Logistic Organ Dysfunction-2 score (PELOD-2) score had both a good discrimination and calibration, allowing to describe the clinical outcome of critically ill children throughout their stay. This score is increasingly used in clinical trials in specific subpopulation. Our objective was to assess the performance of the PELOD-2 score in a subpopulation of critically ill children requiring plasma transfusions.MethodsThis was an ancillary study of a prospective observational study on plasma transfusions over a 6-week period, in 101 PICUs in 21 countries. All critically ill children who received at least one plasma transfusion during the observation period were included. PELOD-2 scores were measured on days 1, 2, 5, 8, and 12 after plasma transfusion. Performance of the score was assessed by the determination of the discrimination (area under the ROC curve: AUC) and the calibration (Hosmer–Lemeshow test).ResultsFour hundred and forty-three patients were enrolled in the study (median age and weight: 1 year and 9.1 kg, respectively). Observed mortality rate was 26.9 % (119/443). For PELOD-2 on day 1, the AUC was 0.76 (95 % CI 0.71–0.81) and the Hosmer–Lemeshow test was p = 0.76. The serial evaluation of the changes in the daily PELOD-2 scores from day 1 demonstrated a significant association with death, adjusted for the PELOD-2 score on day 1.ConclusionsIn a subpopulation of critically ill children requiring plasma transfusion, the PELOD-2 score has a lower but acceptable discrimination than in an entire population. This score should therefore be used cautiously in this specific subpopulation. |
| مصطلحات الفهرس: | Children, Critical care, Multiple organ failure, Outcome, Plasma transfusion, Score, Contribution to Journal |
| URL: | doi:10.1186/s13613-016-0197-6 Karam, Oliver, Demaret, Pierre, Duhamel, Alain, Shefler, Alison, Spinella, Philip C., Stanworth, Simon J., Tucci, Marisa, Leteurtre, Stéphane, Butt, Warwick, Delzoppo, Carmel, Bain, Kym, Erickson, Simon, Smalley, Nathan, Dorofaeff, Tavey, Long, Debbie, Wiseman, Greg, Clénent de Cléty, Stéphan, Berghe, Caroline, de Jaeger, Annick, Trippaerts, Marc, Willems, Ariane, Rooze, Shancy, De Dooy, Jozef, Gilfoyle, Elaine, Wohlgemuth, Lynette, Dumitrascu, Mariana, Withington, Davinia, Hickey, Julia, Choong, Karen, Sanders, Lois, Morrison, Gavin, Tijssen, Janice, Wensley, David, Krahn, Gordon, Dugas, Marc Andre, Gosselin, Louise, Santschi, Miriam, Von Dessauer, Bettina, Ordenes, Nadia, Afshari, Arash, Andersen, Lasse Hoegh, Nilsson, Jens Christian, Johansen, Mathias, Baek Jensen, Anne Mette, Campos Mino, Santiago, Grunauer, Michelle, Joram, Nicolas, Roullet-Renoleau, Nicolas, Javouhey, Etienne, Cour-Andlauer, Fleur, Portefaix, Aurélie, Brissaud, Olivier, Guichoux, Julie, Payen, Valérie, Léger, Pierre Louis, Afanetti, Mickael, Mortamet, Guillaume, Maria, Matthieu, Breining, Audrey, Tissieres, Pierre, Dorkenoo, Aimée, Deho, Anna, Steinherr, Harry, Nikolaou, Filippia, Camporesi, Anna, Mario, Federica, Kawasaki, Tatsuya, Miura, Shinya, Beca, John, Rea, Miriam, Sherring, Claire, Bushell, Tracey, Bentsen, Gunnar, Dinis, Alexandra, Pereira, Gabriela, Vieira, Marisa, Moniz, Marta, Alshehri, Saleh, Alasnag, Manal, Pisarcikova, Maria, Jordan, Iolanda, Balcells, Joan, Perez-Ferrer, Antonio, de Vicente Sánchez, Jesús, Vazquez Moyano, Marta, Morales Martinez, Antonio, Lopez-Herce, Jesus, Solana, Maria Jose, Flores González, Jose Carlos, Alonso, Maria Teresa, Nieto Faza, Manuel, Perez, Marie Hélène, Amiet, Vivianne, Doell, Carsten, Bordessoule, Alice, Cochius-den Otter, Suzan, Kapitein, Berber, Kneyber, Martin, Brierley, Joe, Rea, Vanessa, McKeever, Stephen, Kelleher, Andrea, Scholefield, Barney, Top, Anke, Kelly, Nicola, Virdee, Satnam, Davis, Peter, George, Susan, Hawkins, Kay C., McCall |
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